Highlights of 2024: Tregs immunometabolism and how to counter inflammatory niches.

IF 3.2 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2025-05-04 DOI:10.1111/imcb.70027

Nicolas Valentini, Christopher J Requejo Cier, Caroline Lamarche

引用次数: 0

Abstract

In this article for the Highlights of 2024 Series, we discuss recent discoveries in Treg immunometabolism, which reveal how inflammatory niches alter Treg fate and function through distinct metabolic cues. Key findings include IL-21-driven mitochondrial dysfunction, lactate-enhanced OXPHOS via MGAT1, sphingolipid-dependent Treg differentiation in tumors, ferroptosis susceptibility under high-fat diets, and sex-specific adipose Treg subsets modulating glucose homeostasis. Together, these insights highlight potential metabolic targets to restore Treg function in inflammatory diseases and cancer.

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2024年的亮点：Tregs免疫代谢和如何对抗炎症利基。

在2024系列的这篇文章中，我们讨论了Treg免疫代谢的最新发现，这些发现揭示了炎症利基如何通过不同的代谢线索改变Treg的命运和功能。主要发现包括il -21驱动的线粒体功能障碍，乳酸通过MGAT1增强的OXPHOS，鞘脂依赖性Treg在肿瘤中的分化，高脂肪饮食下的铁中毒易感性，以及调节葡萄糖稳态的性别特异性脂肪Treg亚群。总之，这些见解突出了在炎症性疾病和癌症中恢复Treg功能的潜在代谢靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.