Relationship Between Cardiac Troponin I Concentration and Myocardial Function in Hypertrophic Cardiomyopathy Cats With or Without Left Ventricular Outflow Tract Obstruction.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-05-01 DOI:10.3390/ani15091313

Shuji Satomi, Ryohei Suzuki, Yunosuke Yuchi, Yayoi Yoshii, Haruka Kanno, Takahiro Teshima, Hirotaka Matsumoto

引用次数: 0

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats. HCM is classified into obstructive HCM (HOCM) and non-obstructive HCM (HNCM) forms based on the presence or absence of left ventricular outflow tract obstruction (LVOTO). In humans, LVOTO is a known poor prognostic factor and a target for therapeutic intervention. In contrast, LVOTO has been reported not to contribute to prognosis in cats. This study demonstrated significant correlations between cTnI levels and a maximal LV outflow tract velocity (LVOTV). This finding suggests that LVOTO is associated with myocardial cell injury.

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伴有或不伴有左心室流出道梗阻的肥厚型心肌病猫心肌肌钙蛋白I浓度与心肌功能的关系

肥厚性心肌病（HCM）是猫最常见的心脏病。根据是否存在左心室流出道阻塞（LVOTO）， HCM分为阻塞性HCM （HOCM）和非阻塞性HCM （HNCM）。在人类中，LVOTO是一种已知的不良预后因素，也是治疗干预的目标。相比之下，据报道LVOTO对猫的预后没有影响。本研究表明cTnI水平与最大左室流出道流速（LVOTV）之间存在显著相关性。这一发现提示LVOTO与心肌细胞损伤有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).