Carrier Free 1,2,3,4,6-O-Pentagalloylglucose Nanoparticles for Treatment of Acute Lung Injury.

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-05-21 Epub Date: 2025-05-08 DOI:10.1021/acs.bioconjchem.5c00197

Qi Zhang, Ying Wang, Zixuan Yang, Zhiming Xin, Haohua Deng, Wei Chen

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引用次数: 0

Abstract

Acute lung injury (ALI) is a severe lung disease with a high mortality rate, and novel therapeutic strategies must be developed crucially. The amelioration of inflammation and oxidative stress is a promising strategy for alleviating ALI. 1,2,3,4,6-O-pentagalloylglucose (PGG) has a pronounced therapeutic effect on ALI, with excellent anti-inflammatory and antioxidant effects. However, poor solubility and low bioavailability have affected its clinical application. In this study, carrier-free PGG nanoparticles (PGG NPs) were prepared by antisolvent precipitation method. PGG NPs have been engineered to improve solubility, sustained release behavior, and higher bioavailability than free PGG. Moreover, the pharmacodynamic results showed that the remarkable protective effect of PGG NPs on ALI in rats is better than that of free PGG, which is related to the activation of Nrf2/Keap1/HO-1/NLRP3 pathway. Overall, this study not only demonstrates the efficacy and safety of PGG against ALI, but also holds promise as a carrier-free nanodrug system.

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无载体1,2,3,4,6- o -五五烯基葡萄糖纳米颗粒治疗急性肺损伤

急性肺损伤（ALI）是一种高死亡率的严重肺部疾病，迫切需要新的治疗策略。改善炎症和氧化应激是缓解ALI的一个有希望的策略。1,2,3,4,6- o -五没食子糖（PGG）对ALI有明显的治疗作用，具有良好的抗炎和抗氧化作用。但其溶解度差、生物利用度低，影响了其临床应用。本研究采用反溶剂沉淀法制备无载体PGG纳米粒子（PGG NPs）。PGG NPs被设计成改善溶解度、缓释行为和比游离PGG更高的生物利用度。此外，药效学结果显示，PGG NPs对大鼠ALI的保护作用显著优于游离PGG，这与Nrf2/Keap1/HO-1/NLRP3通路的激活有关。总之，本研究不仅证明了PGG抗ALI的有效性和安全性，而且有望成为一种无载体的纳米药物系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.