Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-25 DOI:10.1039/D5OB00554J

Chuanquan Chu, Yu Liu, Min Mao, Dahan Wang, Jinbing Liu, Huaixin Wei, Mingming Yu and Jinhui Cai

引用次数: 0

Abstract

In this work, we demonstrate the synthesis of a variety of 2,5-disubstituted 1,3,4-thiadiazoles in 28–85% yields via three-component cyclization of 2-methylquinolines, arylhydrazides, and S powder under metal-free conditions. This approach stands out due to its broad substrate scope, excellent functional group tolerance, additive-free nature, base-free nature, easy operation, and simple reaction system. This work offers a simple, concise, and convenient pathway for the assembly of a variety of 1,3,4-thiadiazoles, which is complementary to previous methods.

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无金属条件下单质硫三组分环化合成1,3,4-噻二唑。

在这项工作中，我们证明了在无金属条件下，通过2-甲基喹啉、芳酰肼和S粉的三组分环化，以28-85%的产率合成了多种2,5-二取代1,3,4-噻二唑。该方法具有底物范围广、官能团耐受性好、无添加剂、无碱、操作方便、反应体系简单等特点。这项工作为各种1,3,4-噻二唑的组装提供了一种简单、简洁、方便的途径，是对以往方法的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.