Experimental Investigation of the Applicability of the Stress-Based and Strain-Based Hemolysis Models for Short-Term Stress Peaks Typical for Rotary Blood Pumps

IF 2.3 3区 医学 Q3 ENGINEERING, BIOMEDICAL
Michael Lommel, Vera Froese, Henri Wolff, Nico Dirkes, Katharina Vellguth, Marek Behr, Ulrich Kertzscher
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引用次数: 0

Abstract

Background

Although flow simulations have become more accurate, hemolysis prediction models still show large deviations from measured values in blood-carrying devices. To develop and validate more accurate models, specific hemolysis experiments are needed to determine the influence of parameters on hemolysis, such as stress type and exposure time typical for rotary blood pumps (RBPs).

Methods

In order to investigate the applicability of the hemolysis models to the flow in RBPs, this study performed experiments with human whole blood in three differently shaped flow channels that generate short-term stress peaks. CFD simulations were performed and the applicability of the stress-based and strain-based hemolysis models was investigated by comparing them with the experimental results.

Results

Low and statistically non-significant hemolysis was measured for all geometries and 1200 load repetitions. The CFD simulations determined scalar shear stresses up to 1500 Pa with exposure times in the millisecond range. The stress-based hemolysis model overestimated hemolysis by several orders of magnitude and predicted significant differences between the three flow channels. The strain-based hemolysis model predicted low and approximately equal hemolysis, in agreement with the experimental results.

Conclusion

The results suggest that the stress-based hemolysis model is not appropriate for the applied short-term stress peaks. The strain-based model, which considers the deformation of the RBCs over time, appears to be more appropriate for this type of flow. This implies a similar relationship for RBPs, where these short-term stress peaks are typical.

Abstract Image

基于应力和应变的溶血模型对旋转血泵典型短期应力峰值适用性的实验研究。
背景:尽管血流模拟已经变得更加精确,但在血液输送装置中,溶血预测模型仍然显示出与测量值的较大偏差。为了开发和验证更准确的模型,需要进行具体的溶血实验来确定参数对溶血的影响,例如旋转血泵(rbp)的典型应激类型和暴露时间。方法:为了研究溶血模型对rbp血流的适用性,本研究在三种不同形状的血流通道中进行了人体全血实验,这些通道会产生短期应激峰值。通过CFD模拟,对比了基于应力和应变的溶血模型与实验结果的适用性。结果:所有几何形状和1200次负荷重复均测量到低且无统计学意义的溶血。CFD模拟确定了高达1500 Pa的标量剪切应力,暴露时间在毫秒范围内。基于应力的溶血模型将溶血量高估了几个数量级,并预测了三种血流通道之间的显著差异。基于菌株的溶血模型预测溶血量低且近似相等,与实验结果一致。结论:基于应激的溶血模型不适用于应用的短期应激峰值。基于应变的模型考虑了红细胞随时间的变形,似乎更适合这种类型的流动。这意味着rbp也有类似的关系,这些短期压力峰值是典型的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Artificial organs
Artificial organs 工程技术-工程:生物医学
CiteScore
4.30
自引率
12.50%
发文量
303
审稿时长
4-8 weeks
期刊介绍: Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.
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