Histone variants: expanding the epigenetic potential of neurons one amino acid at a time

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-06-01 DOI:10.1016/j.tibs.2025.03.015

Bradley J. Lukasak , Erica Korb

引用次数: 0

Abstract

Replication-independent histone variants play an essential role in postmitotic neurons. Here, we review how the subtle sequence differences of histone variants compared to their canonical counterparts underly neuronal function. We focus on variants H3.3, H2A.Z, H2A.X, macroH2A, and H2BE; all of which contain divergent sequences that coordinate a diverse set of outcomes. In particular, we highlight their role in neuronal development, plasticity, and memory, with an emphasis on how single amino acid changes can mediate these complex functions. Lastly, we comment on an emerging field of study evaluating the link between histone variants and neurological disorders. Future studies of histone variants will be important to furthering our understanding of neuronal function.

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组蛋白变异：一次一个氨基酸扩展神经元的表观遗传潜能。

复制无关的组蛋白变异在有丝分裂后神经元中起重要作用。在这里，我们回顾了组蛋白变体的细微序列差异与它们的规范对应物在神经元功能下的差异。我们专注于变体H3.3, H2A。Z, H2A。X， macroH2A和H2BE；所有这些都包含不同的序列来协调不同的结果。特别是，我们强调了它们在神经元发育，可塑性和记忆中的作用，重点是单个氨基酸的变化如何介导这些复杂的功能。最后，我们评论了一个新兴的研究领域，评估组蛋白变异和神经系统疾病之间的联系。未来对组蛋白变异的研究将对我们进一步了解神经元功能具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.