From Glycemic Control to Gut Telescoping: Intussusception in a Patient on a Glucagon-Like Peptide-1 Receptor Agonist.

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely utilized for managing diabetes and obesity due to their efficacy in improving glycemic control and promoting weight loss. However, their gastrointestinal effects, such as slowed motility, may lead to adverse outcomes, including small bowel obstruction. Intussusception, a rare complication in adults, has been sparsely reported with GLP-1RA use. We present a 32-year-old woman with iron deficiency anemia who was incidentally diagnosed with transient small bowel intussusception on computed tomography enterography while on semaglutide therapy. No evidence of obstruction or pathological lead point was identified, and follow-up imaging showed resolution without intervention. This case suggests a possible link between GLP-1RA therapy and intussusception, likely secondary to altered gastrointestinal motility. Clinicians should remain vigilant for rare complications associated with GLP-1RAs, particularly in patients presenting with gastrointestinal symptoms. Further studies are warranted to elucidate this association.