Protective Effects of Melatonin and Bee Pollen on Hematotoxicity and Hepatorenal Toxicity Induced by Long-Term Intake of Gabapentin in Female Albino Rats.
Hanan A Okail, Mohamed F El Sayed, Mohamed A Adly, Walaa Magdy Abd Elsamei
{"title":"Protective Effects of Melatonin and Bee Pollen on Hematotoxicity and Hepatorenal Toxicity Induced by Long-Term Intake of Gabapentin in Female Albino Rats.","authors":"Hanan A Okail, Mohamed F El Sayed, Mohamed A Adly, Walaa Magdy Abd Elsamei","doi":"10.1007/s12013-025-01731-4","DOIUrl":null,"url":null,"abstract":"<p><p>Gabapentin (GBN) is an anti-seizure medication that is also used to treat nerve pain and other diseases. However, its misuse is currently a growing worry, as it may pose a significant health danger. The present study aimed to evaluate the protective effect of melatonin (MEL) and bee pollen (BP) as antioxidants against GBN-induced hematotoxicity and hepatorenal toxicity in female Albino rats. In this study, fifty-six adult female albino rats were divided into seven groups (n = 8 each), served as control, GBN, MEL, BP, MEL + GBN, BP + GBN, and MEL + BP + GBN treated groups. Results showed that oral administration of GBN resulted in a hematological toxicity as confirmed by a significant reduction in RBCs, Hb concentration, Ht%, MCV, MCH, platelets as well as altering of leukocyte profiles, WBCs, neutrophils, lymphocytes, monocytes, eosinophils and basophils. The biochemical results of liver and kidney functions showed a significant decrease in serum glucose, total protein, triglycerides, urea and uric acid. However, a significant increase in albumin, cholesterol, creatinine as well as ALP, AST, and ALT liver enzymes compared to the control was found. The oral administration of MEL and BP 12 h before GBN mostly ameliorates the altered hematological and biochemical parameters as well as hepatic and renal histopathological architecture to normal levels. In conclusion, Pre-treatment with MEL and BP, individually or together provided protection against the GBN induced changes in the blood parameters as well as hepatorenal structure and function.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12013-025-01731-4","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Gabapentin (GBN) is an anti-seizure medication that is also used to treat nerve pain and other diseases. However, its misuse is currently a growing worry, as it may pose a significant health danger. The present study aimed to evaluate the protective effect of melatonin (MEL) and bee pollen (BP) as antioxidants against GBN-induced hematotoxicity and hepatorenal toxicity in female Albino rats. In this study, fifty-six adult female albino rats were divided into seven groups (n = 8 each), served as control, GBN, MEL, BP, MEL + GBN, BP + GBN, and MEL + BP + GBN treated groups. Results showed that oral administration of GBN resulted in a hematological toxicity as confirmed by a significant reduction in RBCs, Hb concentration, Ht%, MCV, MCH, platelets as well as altering of leukocyte profiles, WBCs, neutrophils, lymphocytes, monocytes, eosinophils and basophils. The biochemical results of liver and kidney functions showed a significant decrease in serum glucose, total protein, triglycerides, urea and uric acid. However, a significant increase in albumin, cholesterol, creatinine as well as ALP, AST, and ALT liver enzymes compared to the control was found. The oral administration of MEL and BP 12 h before GBN mostly ameliorates the altered hematological and biochemical parameters as well as hepatic and renal histopathological architecture to normal levels. In conclusion, Pre-treatment with MEL and BP, individually or together provided protection against the GBN induced changes in the blood parameters as well as hepatorenal structure and function.
期刊介绍：
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
