{"title":"Sperm DNA Fragmentation and Fertility.","authors":"Jessica Marinaro, Peter N Schlegel","doi":"10.1007/978-3-031-82990-1_13","DOIUrl":null,"url":null,"abstract":"<p><p>Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss. However, due to conflicting study results, limited high-level evidence, multiple clinically available assays, and variable standard reference ranges, precisely how SDF testing should be applied to the evaluation and treatment of infertile men remains controversial. To better understand SDF and its role in clinical practice, this chapter aims to: (1) review the literature that has made SDF such a controversial topic, (2) discuss newly published evidence contributing to this complex discussion, and (3) outline the most recent practice guidelines currently available.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1469 ","pages":"305-332"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/978-3-031-82990-1_13","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss. However, due to conflicting study results, limited high-level evidence, multiple clinically available assays, and variable standard reference ranges, precisely how SDF testing should be applied to the evaluation and treatment of infertile men remains controversial. To better understand SDF and its role in clinical practice, this chapter aims to: (1) review the literature that has made SDF such a controversial topic, (2) discuss newly published evidence contributing to this complex discussion, and (3) outline the most recent practice guidelines currently available.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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