Impact of neurotrophic keratopathy on quality of life: a utility analysis.

IF 2.8 4区 医学 Q1 OPHTHALMOLOGY
Suzan Sargsyan, Sammie E Fung, Tonya S Lee, Kathryn S Park, Brian M Fung, Erik Groessl, Daniel J Ozzello, Bobby S Korn, Don O Kikkawa, Natalie A Afshari, Catherine Y Liu
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引用次数: 0

Abstract

Objective: Neurotrophic keratopathy (NK) is a rare degenerative disease leading to impaired corneal sensation and function. In this study, we measured the utility values associated with NK to better understand the impact of this condition on patients.

Design: Cross-sectional study.

Participants: Twenty-two patients with NK at a university-based outpatient ophthalmology clinic completed a survey.

Methods: Patients were asked questions regarding their eye condition, overall health, and completed the Visual Function Questionnaire (VFQ-25). Health utility was calculated using the time trade-off (TTO) and standard gamble (SG) methods with anchor points of perfect eye function (pf) and perfect health (ph).

Results: Four different utility values for NK were calculated, ranging from 0.69 to 0.86, depending on the measurement method (TTO or SG) and anchor point (pf or ph). Utility values were not significantly associated with age, gender, comorbidities, visual acuity, or severity of NK disease. Role difficulty and dependence (based on a subset of the VFQ-25) were associated with lower utility.

Conclusion: Our study found that NK has a significant impact on quality of life, independent of vision loss. As treatment options for NK are expanding and increasing in efficacy, this study can provide a foundation for future cost-effectiveness analyses on the various treatments for NK.

神经营养性角膜病变对生活质量的影响:效用分析。
目的:神经营养性角膜病(NK)是一种罕见的退行性疾病,导致角膜感觉和功能受损。在这项研究中,我们测量了与NK相关的效用值,以更好地了解这种情况对患者的影响。设计:横断面研究。参与者:一所大学眼科门诊的22名NK患者完成了一项调查。方法:对患者的眼部状况、整体健康状况进行调查,并填写视觉功能问卷(VFQ-25)。健康效用采用时间权衡法(TTO)和标准赌博法(SG)计算,锚点为完美眼功能(pf)和完美健康(ph)。结果:根据测量方法(TTO或SG)和锚点(pf或ph)的不同,计算了NK的四个不同效用值,范围为0.69至0.86。效用值与年龄、性别、合并症、视力或NK疾病的严重程度无显著相关性。角色难度和依赖性(基于VFQ-25的一个子集)与较低的效用相关。结论:我们的研究发现NK对生活质量有显著影响,与视力丧失无关。随着NK治疗方案的扩大和疗效的提高,本研究可以为未来NK各种治疗方法的成本-效果分析提供基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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