Vitamin D and tibial bone density, geometry, and microarchitecture in male military recruits: an observational study and randomized controlled trial.

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Thomas J O'Leary, Rachel M Izard, Sarah Jackson, Neil P Walsh, Alexander T Carswell, Samuel J Oliver, Donald Allan, Lesley E Rhodes, Jonathan C Y Tang, William D Fraser, Julie P Greeves
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引用次数: 0

Abstract

Vitamin D may mitigate bone stress injuries in military training by modulating changes in bone. This cross-sectional observational study (Study 1) and randomized controlled trial (Study 2) investigated associations between vitamin D metabolites and tibial structure and density, and the effect of vitamin D supplementation on tibial adaptations to military training. A total of 343 (Study 1) and 194 (Study 2) male British Army recruits participated. Circulating vitamin D metabolites (biologically "active" and "inactive") and tibial structure were measured in participants during week 1 and week 12 (Study 2 only) of initial military training. Associations between vitamin D metabolites and HRpQCT outcomes at week 1 were tested in Study 1. Participants in Study 2 were randomly assigned to vitamin D (oral pill or simulated sunlight) or placebo (placebo pill or placebo simulated sunlight) supplementation for 12 wk designed to achieve vitamin D sufficiency. There was no association between total 25(OH)D or vitamin D receptor single-nucleotide polymorphisms and any measure of density, geometry, or microarchitecture (p ≥ .063). Higher 1,25(OH)2D was associated with lower cortical porosity and perimeter (p ≤ .040). Higher total 24,25(OH)2D was associated with higher trabecular number and lower trabecular thickness (p = .016). Higher 25(OH)D:24,25(OH)2D (VMR 1) was associated with higher trabecular thickness, trabecular separation, and cortical porosity (p ≤ .034). Higher 1,25(OH)2D:24,25(OH)2D (VMR 2) was associated with lower trabecular number, and higher trabecular spacing and thickness (p ≤ .035). There was no effect of vitamin D supplementation on any tibial outcome. Training decreased trabecular area (-0.1%), thickness (-4.4%), and separation (-2.1%), and increased cortical thickness (0.8%) and area (0.9%) (p ≤ .042). Vitamin D metabolites and their ratios were associated with tibial size and microarchitecture, but vitamin D supplementation had no impact on the adaptive response to military training.

维生素D与男性新兵胫骨骨密度、几何形状和微结构:一项观察性研究和随机对照试验。
维生素D可能通过调节骨骼的变化来减轻军事训练中的骨应激损伤。这项横断面观察性研究(研究1)和随机对照试验(研究2)调查了维生素D代谢物与胫骨结构和密度之间的关系,以及补充维生素D对胫骨适应军事训练的影响。共有343名(研究1)和194名(研究2)男性英国陆军新兵参与。在第1周(仅研究1)和第12周的初始军事训练中,对参与者的循环维生素D代谢物(生物“活性”和“非活性”)和胫骨结构进行了测量。研究1测试了第1周维生素D代谢物与HRpQCT结果之间的关系。研究2的参与者被随机分配服用维生素D(口服药片或模拟阳光)或安慰剂(安慰剂药片或安慰剂模拟阳光)补充剂,为期12周,旨在达到维生素D的充足性。总25(OH)D或维生素D受体单核苷酸多态性与密度、几何形状或微结构的任何测量均无关联(p≥0.063)。较高的1,25(OH)2D与较低的皮质孔隙度和周长相关(p≤0.040)。较高的总24,25(OH)2D与较高的小梁数量和较低的小梁厚度相关(p = 0.016)。较高的25(OH)D:24,25(OH)2D (VMR 1)与较高的小梁厚度、小梁分离和皮质孔隙度相关(p≤0.034)。1,25(OH)2D:24,25(OH)2D (vmr2)越高,小梁数量越少,小梁间距和厚度越高(p≤0.035)。补充维生素D对任何胫骨预后没有影响。训练减少小梁面积(-0.1%)、厚度(-4.4%)和分离(-2.1%),增加皮质厚度(0.8%)和面积(0.9%)(p≤0.042)。维生素D代谢产物及其比值与胫骨大小和微结构有关,但补充维生素D对军事训练的适应性反应没有影响。
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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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