Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women's Health Initiative participants.

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diddier Prada, Vrinda Kalia, Feng Gao, Kathryn Rexrode, Charles Kooperberg, Alex Reiner, Raji Balasubramanian, Hui-Chen Wu, Carolyn J Crandall, Carol Horowitz, David Cantu-de-Leon, Claudia Garcia-Cuellar, Andrea Ramirez, Jonathan González-Ruiz, Duanping Liao, Jeff Yanosky, James D Stewart, Eric A Whitsel, Andrea A Baccarelli
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Abstract

Ambient air pollution has been associated with bone damage. However, no studies have evaluated the metabolomic response to air pollutants and its potential influence on bone health in postmenopausal women. We analyzed data from Women's Health Initiative (WHI) participants with plasma samples. Whole-body, TH, FN, and spine BMD were determined using DXA at enrollment and follow-up visits (years 1, 3, 6, and 9 visits; Y1, Y3, Y6, Y9, respectively). Geocoded, participant address-specific, daily particulate matter nitrogen oxide (NO), nitrogen dioxide (NO2), particulate matter ≤10 μm (PM10), and sulfur dioxide (SO2) concentrations were averaged over 1-, 3-, and 5-yr periods before plasma sampling for metabolomic assessments (at baseline and Y1 visit). The averages were then integrated using masked WHI participant identifiers. Statistical analyses included multivariable-adjusted linear mixed models, pathway analyses, and mediation modeling. At all averaging periods, NO, NO2, and SO2, but not PM10, were associated with taurine, inosine, and C38:4 phosphatidylethanolamine (PE). We found a partial potential mediation of C38:4 PE in the association between 1-yr average NO and LS BMD (p-value: .032). This is the first study suggesting phospholipids may partially mediate air pollution-related bone damage in postmenopausal women.

空气污染相关骨损伤的代谢组学评价及其在妇女健康倡议参与者中的潜在中介作用。
环境空气污染与骨骼损伤有关。然而,尚无研究评估绝经后妇女对空气污染物的代谢组学反应及其对骨骼健康的潜在影响。我们分析了来自WHI参与者的血浆样本数据。在入组和随访时(第1,3,6和9年)使用双能x线骨密度仪(DXA)测定全身、全髋关节、股骨颈和脊柱骨密度;分别是Y1 Y3 Y6 Y9)在进行代谢组学评估的血浆采样前,对地理编码的、参与者特定地址的每日颗粒物氮氧化物(NO)、二氧化氮(NO2)、颗粒物≤10 μm (PM10)和二氧化硫(SO2)浓度进行了1年、3年和5年的平均研究。(基线及第1次访视)。然后使用蒙面WHI参与者标识符整合平均值。统计分析包括多变量调整线性混合模型、路径分析和中介模型。在所有平均时期,NO、NO2和SO2与牛磺酸、肌苷和C38:4磷脂酰乙醇胺(PE)相关,但PM10无关。我们发现C38:4 PE在1年平均NO和腰椎骨密度之间存在部分电位中介作用(p值:0.032)。这是第一个表明磷脂可能部分介导空气污染相关的绝经后妇女骨损伤的研究。
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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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