Reliable sensory processing of superficial cortical interneurons is modulated by behavioral state.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-05-09 DOI:10.1016/j.celrep.2025.115678

Carolyn G Sweeney, Maryse E Thomas, Christine Junhui Liu, Lucas G Vattino, Kasey E Smith, Anne E Takesian

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引用次数: 0

Abstract

GABAergic interneurons in cortical layer 1 (L1) integrate sensory and top-down inputs to modulate network activity and support learning-related plasticity. However, little is known about how sensory inputs drive L1 interneuron activity. We used two-photon calcium imaging to measure sound-evoked responses in two L1 interneuron populations expressing vasoactive intestinal peptide (VIP) or neuron-derived neurotrophic factor (NDNF) in mouse auditory cortex. We found that L1 interneurons respond to both simple and complex sounds, but their responses are highly variable across trials. Despite this variability, these interneurons respond reliably to a narrow range of stimuli, reflecting selectivity for specific spectrotemporal sound features. Response reliability was modulated by behavioral state and predicted by the activity of neighboring interneurons. These findings reveal that L1 interneurons exhibit sensory tuning and identify the modulation of response reliability as a potential mechanism by which L1 relays state-dependent cues to shape sensory representations.

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皮层表层中间神经元的可靠感觉加工受行为状态的调节。

皮层1层（L1） gaba能中间神经元整合感觉和自上而下的输入来调节网络活动并支持学习相关的可塑性。然而，对于感觉输入如何驱动L1中间神经元的活动知之甚少。我们使用双光子钙成像技术测量了小鼠听觉皮层中表达血管活性肠肽（VIP）或神经元源性神经营养因子（NDNF）的两个L1中间神经元群的声诱发反应。我们发现L1中间神经元对简单和复杂的声音都有反应，但它们的反应在不同的试验中变化很大。尽管存在这种可变性，但这些中间神经元对狭窄范围的刺激做出可靠的反应，反映了对特定光谱时间声音特征的选择性。反应信度受行为状态的调节，并由邻近中间神经元的活动预测。这些发现揭示了L1中间神经元表现出感觉调节，并确定了反应可靠性的调节是L1传递状态依赖线索以形成感觉表征的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.