{"title":"The Relationship Between Magnesium Depletion Score and Kidney Stone Risk in Gout Patients: a Mediation Analysis.","authors":"Jing Liu, Yu Lei","doi":"10.1007/s12011-025-04638-6","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigated the association and mediating mechanisms between magnesium depletion score (MDS) and kidney stones (KDS) in gout patients through a cross-sectional analysis. Logistic regression analysis of 502 gout patients revealed a significant positive association between MDS grade and KDS (OR = 2.14, 95% CI: 1.78-2.58), with the risk remaining elevated in the MDS4 group after adjusting for confounders (OR = 6.25, 95% CI: 2.38-16.44).Causal mediation analysis indicated that MDS fully explained the effect of serum uric acid (SUA) on KDS, suggesting that disrupted magnesium metabolism plays a key role in gout-related kidney injury. Subgroup analysis revealed an increased risk of KDS in obese, hypertensive, and diabetic patients with MDS. MDS should be incorporated into clinical risk assessments for gout, and magnesium supplementation or combined uric acid-lowering therapy should be recommended for high-risk groups to prevent KDS.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Trace Element Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12011-025-04638-6","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigated the association and mediating mechanisms between magnesium depletion score (MDS) and kidney stones (KDS) in gout patients through a cross-sectional analysis. Logistic regression analysis of 502 gout patients revealed a significant positive association between MDS grade and KDS (OR = 2.14, 95% CI: 1.78-2.58), with the risk remaining elevated in the MDS4 group after adjusting for confounders (OR = 6.25, 95% CI: 2.38-16.44).Causal mediation analysis indicated that MDS fully explained the effect of serum uric acid (SUA) on KDS, suggesting that disrupted magnesium metabolism plays a key role in gout-related kidney injury. Subgroup analysis revealed an increased risk of KDS in obese, hypertensive, and diabetic patients with MDS. MDS should be incorporated into clinical risk assessments for gout, and magnesium supplementation or combined uric acid-lowering therapy should be recommended for high-risk groups to prevent KDS.
期刊介绍：
Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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