Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation.

IF 3.2 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2025-04-19 DOI:10.1111/imcb.70021

Xin Shen, Xianzhi Gao, Lie Wang

引用次数: 0

Abstract

In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from the gut to the kidneys, contributing to renal fibrosis. Their functions are metabolically regulated, with proteins such as nucleophosmin 1 and Tox2 influencing oxidative phosphorylation and glycolysis, respectively. ILC3s also express immune checkpoint molecules (e.g. cytotoxic T-lymphocyte antigen 4 and programmed cell death1), which modulate inflammation. These findings highlight the tissue-specific roles of ILC3s and the need for targeted immunotherapies.

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2024年的亮点：ILC3s在粘膜免疫和炎症中的多方面作用。

在2024系列的重点文章中，我们讨论了第3组先天淋巴样细胞（ILC3s）的研究，揭示了它们在粘膜免疫和炎症中的复杂作用。ILC3s可以从肠道迁移到肾脏，导致肾脏纤维化。它们的功能受代谢调节，核磷蛋白1和Tox2等蛋白分别影响氧化磷酸化和糖酵解。ILC3s还表达调节炎症的免疫检查点分子（如细胞毒性t淋巴细胞抗原4和程序性细胞死亡1）。这些发现强调了ILC3s的组织特异性作用和靶向免疫治疗的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.