Pro-inflammatory Cytokines, Ferroptosis, and Cancer.

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2025-01-01 DOI:10.32607/actanaturae.27547

A A Vartanian, V S Kosorukov

引用次数: 0

Abstract

Ferroptosis, iron-dependent regulated cell death, is induced by the polyunsaturated fatty acid peroxidation of membrane phospholipids and is controlled by glutathione peroxidase 4. In recent years, convincing evidence has emerged, demonstrating a close relationship between chemo-, radio-, immuno-, and targeted therapy resistance and ferroptosis resistance. In this review, we discuss the basic principles of ferroptosis in cancer. Considerable attention is paid to the formation of an immunosuppressive tumor microenvironment. The main focus is centered on the involvement of the excessive, chronic production of pro-inflammatory cytokines in ferroptosis resistance development in tumors.

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促炎细胞因子，铁下垂和癌症。

铁依赖性调节细胞死亡，由膜磷脂的多不饱和脂肪酸过氧化引起，并由谷胱甘肽过氧化物酶4控制。近年来出现了令人信服的证据，表明化疗、放射、免疫和靶向治疗耐药与铁下垂耐药之间存在密切关系。在这篇综述中，我们讨论了铁下垂在癌症中的基本原理。免疫抑制肿瘤微环境的形成引起了相当大的关注。主要的焦点集中在过度的，慢性生产的促炎细胞因子参与铁下垂在肿瘤的耐药发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.