Current Diagnostics and management of submandibular space schwannoma: a systematic review.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2025-04-22 DOI:10.1080/00016489.2025.2486611

Srivatsa Surya Vasudevan, Estephania Candelo, Anyull D Bohorquez Caballero, Katerina J Green, Tiba Yamin Kandrikar, Jeffrey R Janus

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引用次数: 0

Abstract

Background: Submandibular space schwannomas (SSS) are rare tumors originating from the neural sheath in the submandibular region with varied prognoses.

Objective: The primary objective was to evaluate the current diagnostic and management outcomes of SSS.

Material and methods: PubMed, Embase, Science Direct, and Web of Science were reviewed for articles from inception through January 2025. Fisher's test was used to calculate the difference in outcomes between extraglandular (EG) and intraglandular (IG) subtypes.

Results: A total of 44 studies with 47 patients were included with a mean age (SD) of 42.8 (19.3) years. Hypoglossal nerve (43.3%) and lingual nerve (36.6%) were the primary nerve of origin for SSS, with significantly higher rates of hypoglossal nerve origin in EG-SSS than IG-SSS (p = .008). Sensitivity analysis of preoperative biopsy showed higher sensitivity rates with core biopsy compared to fine-needle aspiration cytology (FNAC) (85.7% vs. 38.7%) in SSS diagnosis. IG schwannomas are more likely to undergo submandibular gland excision (p = .002) than EG schwannoma.

Conclusion: Core biopsy demonstrated superior sensitivity compared to FNAC, establishing it as the preferred diagnostic tool. The hypoglossal nerve was the most identified nerve of origin.

Significance: This review offers a comprehensive insight into the preoperative and perioperative management of SSS subtypes for surgeon decisions.

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目前的诊断和治疗下颌间隙神经鞘瘤：一个系统的回顾。

背景：下颌骨间隙神经鞘瘤（SSS）是一种起源于下颌骨神经鞘的罕见肿瘤，预后不一。目的：主要目的是评估当前SSS的诊断和治疗结果。材料和方法：PubMed， Embase， Science Direct和Web of Science从成立到2025年1月的文章进行了审查。使用Fisher检验来计算腺外（EG）亚型和腺内（IG）亚型之间的结果差异。结果：共纳入44项研究，47例患者，平均年龄42.8（19.3）岁。舌下神经（43.3%）和舌神经（36.6%）是SSS的主要神经来源，EG-SSS的舌下神经来源率明显高于IG-SSS （p = 0.008）。术前活检敏感性分析显示，与细针穿刺细胞学（FNAC）相比，核心活检对SSS诊断的敏感性更高（85.7%对38.7%）。IG神经鞘瘤比EG神经鞘瘤更容易行颌下腺切除术（p = 0.002）。结论：与FNAC相比，核心活检显示出更高的敏感性，使其成为首选的诊断工具。舌下神经是最容易识别的神经起源。意义：本综述对SSS亚型的术前和围手术期管理提供了全面的见解，为外科医生的决策提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.