Metal-free iodosulfonylation of alkynes to access (E)-β-iodovinyl sulfones in water.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-12 DOI:10.1039/d5ob00483g

Guiting Peng, Fang Wei, Jiang Bai, Haixin Ding, Xin Yu, Qiang Xiao

引用次数: 0

Abstract

With the escalating concerns regarding environmental pollution caused by organic solvents, chemists are increasingly focusing on conducting organic reactions in water, nature's chosen solvent for chemical synthesis. Herein, the development of metal-free iodosulfonylation of alkynes with p-toluenesulfonyl cyanide and NIS for the synthesis of (E)-β-iodovinyl sulfones in water is reported. This reaction gives the desired products in good to excellent yields with high regio- and stereoselectivity by using water as a green solvent at room temperature. This reaction could be readily scaled up, and synthetic application was also studied.

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烷基的无金属碘磺酰化以获得水中的(E)-β-碘乙烯基砜。

随着人们对有机溶剂对环境污染的日益关注，化学家们越来越关注在自然界选择的化学合成溶剂水中进行有机反应。本文报道了炔与对甲苯磺酰氰和NIS在水中合成(E)-β-碘乙烯基砜的无金属碘磺酰化反应的进展。该反应以水为绿色溶剂，在室温条件下，以较高的区域选择性和立体选择性，得到了理想的收率。该反应易于放大，并对其在合成中的应用进行了研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.