Hyaluronic Acid Microneedles Loaded with Chinese Herbal Extracts as an Intradermal Delivery System for Hair Regeneration.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-12 DOI:10.1021/acs.biomac.5c00018

Jiaquan Hong, Bocheng Xu, Xiaole Hu, Chun Liu, Hongsheng Liu, Jinhuan Tian, Lihua Li, Shan Ding, Changren Zhou, Lu Lu

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引用次数: 0

Abstract

Androgenic alopecia is one of the most common chronic problems for dermatologists worldwide. Some Chinese herbal extracts have been shown to promote hair growth, but the active ingredients are difficult to enter the dermis. Therefore, delivering the active ingredients into the dermis becomes a key factor. Herein, Platycladus orientalis leaf extract (PO-ex) was obtained using ethanol as a solvent, and then hyaluronic acid methacrylate/hyaluronic acid (HAMA/HA) hydrogel was loaded with PO-ex to prepare hyaluronic acid microneedles (PO-ex MN). The double cross-linked HAMA/HA provides sufficient mechanical strength to pierce the stratum corneum and deliver PO-ex into the dermis; PO-ex can effectively improve the environment for hair follicle cell proliferation by removing reactive oxygen free radicals; in addition, the self-repair reaction caused by microneedle mechanical stimulation activates the Wnt/β-catenin pathway associated with trauma repair and promotes hair follicle growth. PO-ex MN is a potential therapeutic strategy for the treatment of androgenic alopecia.

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含有中草药提取物的透明质酸微针作为毛发再生的皮内输送系统。

雄激素性脱发是全世界皮肤科医生最常见的慢性问题之一。一些中草药提取物已被证明能促进头发生长，但有效成分很难进入真皮层。因此，将有效成分输送到真皮层成为一个关键因素。本研究以乙醇为溶剂制备侧柏叶提取物（PO-ex），然后将PO-ex负载于透明质酸甲基丙烯酸酯/透明质酸（HAMA/HA）水凝胶制备透明质酸微针（PO-ex MN）。双交联的HAMA/HA提供了足够的机械强度，可以穿透角质层并将PO-ex输送到真皮层；PO-ex通过清除活性氧自由基，有效改善毛囊细胞增殖环境；此外，微针机械刺激引起的自我修复反应激活与创伤修复相关的Wnt/β-catenin通路，促进毛囊生长。PO-ex MN是治疗雄激素性脱发的潜在治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.