Advancements in Using Polymeric Nanoparticles for Blood-Brain Barrier Penetration in Neurological Disorders.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-05-11 DOI:10.1021/acsabm.4c01956

Yuao Wu, Shehzahdi S Moonshi, Hang Thu Ta

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引用次数: 0

Abstract

Neurological disorders and glioblastoma represent a significant global health burden, affecting billions of individuals and contributing to high rates of morbidity and mortality. A primary obstacle in treating these conditions is the presence of the blood-brain barrier (BBB), a protective barrier that restricts the entry of most therapeutic agents into the brain. Despite this challenge, advancements in nanotechnology, specifically the development of polymeric nanoparticles, offer promising solutions for overcoming the BBB. Key strategies include surface modifications like PEGylation to enhance circulation time, receptor-mediated targeting for specific brain cells, and stimuli-responsive nanoparticles that release drugs in response to pH or reactive oxygen species. Ultrasound-guided delivery, intranasal administration, and magnetic nanoparticle guidance further enhance targeted delivery, while multifunctional nanoparticles enable combination therapies. These nanoparticles, with their customizable properties, allow for targeted and sustained delivery of drugs to the central nervous system, providing new hope in the treatment of both neurodegenerative diseases and brain cancers. In this review, we explore recent strategies that exploit polymeric nanoparticles to improve drug delivery across the BBB, highlighting their potential in revolutionizing therapeutic approaches for neurological disorders.

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高分子纳米颗粒用于神经系统疾病血脑屏障穿透的研究进展。

神经系统疾病和胶质母细胞瘤是一个重大的全球健康负担，影响到数十亿人，并导致高发病率和死亡率。治疗这些疾病的主要障碍是血脑屏障（BBB）的存在，这是一种限制大多数治疗药物进入大脑的保护性屏障。尽管存在这一挑战，纳米技术的进步，特别是聚合物纳米颗粒的发展，为克服血脑屏障提供了有希望的解决方案。关键的策略包括表面修饰，如聚乙二醇化，以延长循环时间，受体介导的特定脑细胞靶向，以及刺激反应性纳米颗粒释放药物，以响应pH或活性氧。超声引导给药、鼻内给药和磁性纳米颗粒引导进一步增强了靶向给药，而多功能纳米颗粒使联合治疗成为可能。这些纳米粒子具有可定制的特性，可以将药物靶向和持续地输送到中枢神经系统，为治疗神经退行性疾病和脑癌提供了新的希望。在这篇综述中，我们探讨了利用聚合物纳米颗粒改善血脑屏障药物传递的最新策略，强调了它们在神经系统疾病的革命性治疗方法中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.