Curcumin-Loaded Silver-Based Metal-Organic Frameworks: Efficient Antibacterial and Antioxidant Properties against Escherichia coli and Staphylococcus aureus for Promoting Infected Wound Healing.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-05-19 Epub Date: 2025-05-08 DOI:10.1021/acsabm.5c00275

Jinyan Du, Jinrui Hou, Shiji Liu, Xinyue Wu, Liangde Hu, Wenjiang Xu, Shujuan Zhuo

{"title":"Curcumin-Loaded Silver-Based Metal-Organic Frameworks: Efficient Antibacterial and Antioxidant Properties against Escherichia coli and Staphylococcus aureus for Promoting Infected Wound Healing.","authors":"Jinyan Du, Jinrui Hou, Shiji Liu, Xinyue Wu, Liangde Hu, Wenjiang Xu, Shujuan Zhuo","doi":"10.1021/acsabm.5c00275","DOIUrl":null,"url":null,"abstract":"Slow or noticeably delayed wound healing is frequently intimately linked to bacterial infection and excessive reactive oxygen species (ROS), while the inappropriate usage of antibiotics fuels the rise of bacterial resistance. The innovative materials are desperately needed to eliminate bacteria and effectively accelerate wound healing. In this work, a curcumin-loaded silver-based metal-organic framework (Cur/Ag-MOF) composite nanomaterial was developed, which exhibited good antimicrobial activity, biocompatibility, and drug resistance. Meanwhile, surface-loaded curcumin can effectively eliminate excess free radicals and promote wound healing due to its antioxidative and ROS scavenging properties. Additionally, it was discovered that the application of Cur/Ag-MOF to the site of skin trauma significantly sped up the process of wound closure in mice used as subjects. These findings highlighted its great potential for treating bacterial infection-induced skin injuries and aiding the healing and reconstruction of skin tissues.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4140-4152"},"PeriodicalIF":4.6000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Slow or noticeably delayed wound healing is frequently intimately linked to bacterial infection and excessive reactive oxygen species (ROS), while the inappropriate usage of antibiotics fuels the rise of bacterial resistance. The innovative materials are desperately needed to eliminate bacteria and effectively accelerate wound healing. In this work, a curcumin-loaded silver-based metal-organic framework (Cur/Ag-MOF) composite nanomaterial was developed, which exhibited good antimicrobial activity, biocompatibility, and drug resistance. Meanwhile, surface-loaded curcumin can effectively eliminate excess free radicals and promote wound healing due to its antioxidative and ROS scavenging properties. Additionally, it was discovered that the application of Cur/Ag-MOF to the site of skin trauma significantly sped up the process of wound closure in mice used as subjects. These findings highlighted its great potential for treating bacterial infection-induced skin injuries and aiding the healing and reconstruction of skin tissues.

查看原文本刊更多论文

负载姜黄素的银基金属有机框架：对大肠杆菌和金黄色葡萄球菌有效的抗菌和抗氧化性能，促进感染伤口愈合。

伤口愈合缓慢或明显延迟通常与细菌感染和活性氧（ROS）过多密切相关，而抗生素的不当使用助长了细菌耐药性的上升。人们迫切需要这种创新材料来消除细菌并有效地加速伤口愈合。本文研制了一种负载姜黄素的银基金属-有机骨架（Cur/Ag-MOF）复合纳米材料，该材料具有良好的抗菌活性、生物相容性和耐药性能。同时，表面负载的姜黄素由于其抗氧化和清除活性氧的特性，可以有效地清除多余的自由基，促进伤口愈合。此外，我们还发现，将Cur/Ag-MOF应用于皮肤创伤部位，可以显著加快被试小鼠伤口愈合的过程。这些发现强调了它在治疗细菌感染引起的皮肤损伤和帮助皮肤组织愈合和重建方面的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.