Three timepoint perioperative CEA levels are a prognostic factor for recurrence after adjuvant chemotherapy in patients with Stage II and III colorectal cancer

IF 2.9 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of Gastroenterological Surgery Pub Date : 2024-11-19 DOI:10.1002/ags3.12886

Shodai Mizuno, Kohei Shigeta, Ryosuke Hara, Kyoko Sakamoto, Jumpei Nakadai, Hideo Baba, Hiroto Kikuchi, Yoko Adachi, Takehiro Shimada, Hirofumi Suzumura, Kiyoaki Sugiura, Shimpei Matsui, Ryo Seishima, Koji Okabayashi, Yuko Kitagawa

{"title":"Three timepoint perioperative CEA levels are a prognostic factor for recurrence after adjuvant chemotherapy in patients with Stage II and III colorectal cancer","authors":"Shodai Mizuno, Kohei Shigeta, Ryosuke Hara, Kyoko Sakamoto, Jumpei Nakadai, Hideo Baba, Hiroto Kikuchi, Yoko Adachi, Takehiro Shimada, Hirofumi Suzumura, Kiyoaki Sugiura, Shimpei Matsui, Ryo Seishima, Koji Okabayashi, Yuko Kitagawa","doi":"10.1002/ags3.12886","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To investigate the relationship between the three timepoint perioperative CEA (ttpCEA) calculated at three timepoints and recurrence during the perioperative period in Stage II and III colorectal cancer (CRC) patients.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We performed a multi-institutional retrospective analysis of patients with Stage II and III CRC who underwent surgery and adjuvant chemotherapy from 2010 to 2020. Patient data from three facilities were used as training data, and data from three other facilities were used as validation data. The primary endpoint was the time to recurrence (TTR).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 538 patients were included for the training data. To validate the feasibility of ttpCEA, 329 patients were included for the validation data. Training data patients were categorized as ttpCEA low (<i>n</i> = 365) and ttpCEA high (<i>n</i> = 173). The 5-y TTR was significantly greater in the ttpCEA-low subgroup than in the ttpCEA-high subgroup (84.3% vs. 69.6%, respectively; <i>p</i> < 0.001). Validation data patients were categorized as ttpCEA low (<i>n</i> = 221) and ttpCEA high (<i>n</i> = 108). The 5-y TTR was significantly greater in the ttpCEA-low subgroup than in the ttpCEA-high subgroup (82.9% vs. 68.7%, respectively; <i>p</i> = 0.003).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The ttpCEA calculated from perioperative CEA levels at different timepoints was a prognostic factor for recurrence in Stage II and III CRC patients who underwent adjuvant chemotherapy according to both the training and validation data.</p>\n </section>\n </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"9 3","pages":"496-504"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12886","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Gastroenterological Surgery","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ags3.12886","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

To investigate the relationship between the three timepoint perioperative CEA (ttpCEA) calculated at three timepoints and recurrence during the perioperative period in Stage II and III colorectal cancer (CRC) patients.

Methods

We performed a multi-institutional retrospective analysis of patients with Stage II and III CRC who underwent surgery and adjuvant chemotherapy from 2010 to 2020. Patient data from three facilities were used as training data, and data from three other facilities were used as validation data. The primary endpoint was the time to recurrence (TTR).

Results

A total of 538 patients were included for the training data. To validate the feasibility of ttpCEA, 329 patients were included for the validation data. Training data patients were categorized as ttpCEA low (n = 365) and ttpCEA high (n = 173). The 5-y TTR was significantly greater in the ttpCEA-low subgroup than in the ttpCEA-high subgroup (84.3% vs. 69.6%, respectively; p < 0.001). Validation data patients were categorized as ttpCEA low (n = 221) and ttpCEA high (n = 108). The 5-y TTR was significantly greater in the ttpCEA-low subgroup than in the ttpCEA-high subgroup (82.9% vs. 68.7%, respectively; p = 0.003).

Conclusion

The ttpCEA calculated from perioperative CEA levels at different timepoints was a prognostic factor for recurrence in Stage II and III CRC patients who underwent adjuvant chemotherapy according to both the training and validation data.

查看原文本刊更多论文

三个时间点围手术期CEA水平是II期和III期结直肠癌患者辅助化疗后复发的预后因素

目的探讨二、三期结直肠癌（CRC）患者围手术期三个时间点计算的围手术期CEA （ttpCEA）与围手术期复发的关系。方法：我们对2010年至2020年期间接受手术和辅助化疗的II期和III期结直肠癌患者进行了多机构回顾性分析。来自三个机构的患者数据被用作训练数据，来自另外三个机构的数据被用作验证数据。主要终点为复发时间（TTR）。结果共纳入538例患者。为了验证ttpCEA的可行性，纳入了329例患者作为验证数据。训练数据患者分为ttpCEA低组（n = 365）和ttpCEA高组（n = 173）。ttpcea低亚组的5年TTR显著高于ttpcea高亚组(分别为84.3%和69.6%；p < 0.001)。验证数据患者分为ttpCEA低组（n = 221）和ttpCEA高组（n = 108）。ttpcea低亚组的5年TTR显著高于ttpcea高亚组(分别为82.9%和68.7%；p = 0.003)。结论根据训练和验证数据，根据围手术期不同时间点CEA水平计算的ttpCEA是辅助化疗的II期和III期CRC患者复发的预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊