Hormonal Dynamics of Cervical Cancer: Role of Estrogen and Progesterone

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2025-05-15 DOI:10.1002/cbf.70082

Jyoti Rani, Seema Yadav, Ritu Yadav, Ravindresh Chhabra

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引用次数: 0

Abstract

Cervical cancer remains a significant global health burden, with its etiology intricately linked to hormonal influences such as estrogen and progesterone. The effect of estrogen on cervical cancer is dependent upon factors like estrogen receptor subtype and microenvironmental context. Conversely, progesterone has a more complex role, acting as an inducer as well as inhibitor, by coordinating with tumor suppressor genes and cell proliferation markers. Understanding the interplay among these hormones, HPV infection, and cervical carcinogenesis is crucial for improving current preventive strategies and therapeutic interventions. This review outlines the latest insights on how hormones influence cervical cancer development, highlighting their protective and inhibitory effects. It explores the interaction between HPV oncogenes and hormones in cervical cancer progression. Additionally, it consolidates existing knowledge and identifies future research directions, underscoring the potential of hormone modulation as a therapeutic strategy for cervical cancer.

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宫颈癌的激素动态：雌激素和黄体酮的作用

子宫颈癌仍然是一个重大的全球健康负担，其病因与雌激素和黄体酮等激素的影响有着复杂的联系。雌激素对宫颈癌的影响取决于雌激素受体亚型和微环境背景等因素。相反，黄体酮具有更复杂的作用，通过与肿瘤抑制基因和细胞增殖标志物协调，既可以作为诱导剂，也可以作为抑制剂。了解这些激素、HPV感染和宫颈癌发生之间的相互作用对于改进当前的预防策略和治疗干预措施至关重要。这篇综述概述了激素如何影响宫颈癌发展的最新见解，强调了它们的保护和抑制作用。它探讨了宫颈癌进展中HPV癌基因和激素之间的相互作用。此外，它巩固了现有知识并确定了未来的研究方向，强调了激素调节作为宫颈癌治疗策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.