Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2025-05-15 DOI:10.1111/anec.70090

Feng-Xian Li, Qiao-hong Guo

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引用次数: 0

Abstract

Objective

To simulate thrombotic occlusion of catheters and develop a model for thrombotic occlusion in peripherally inserted central catheters (PICC), providing a framework for research on catheter occlusion and post-occlusion recanalization.

Methods

Following preparatory steps prior to modeling, sterile anticoagulant bovine blood was drawn and injected into the PICC. Subsequently, the catheter tip was clamped and left to stand for 72 h.

Results

A total of 140 catheter models were produced, all of which exhibited thrombosis, resulting in a 100% success rate for intra-catheter thrombus production. Of these, 118 models experienced no blood reflux when the syringe plunger was withdrawn and triggered an infusion pump alarm, achieving a catheter occlusion modeling success rate of 84.29%. There were 127 cases where syringe plunger withdrawal resulted in no blood reflux within the thrombotic catheter occlusion models, yielding an incidence rate of 90.71%, while 13 cases revealed blood reflux mixed with fine thrombosis, with an incidence rate of 9.29%. Additionally, 126 models triggered infusion pump alarms, with an incidence rate of 90%, while 14 models did not trigger alarms due to thrombus overflow at the catheter tip, with an incidence rate of 10%. The infusion pump alarm method and the syringe withdrawal method demonstrated a significant correlation in diagnosing thrombotic catheter occlusion.

Conclusion

The method for modeling thrombotic catheter occlusion used in this study is reliable, producing a model that accurately simulates the fundamental characteristics of thrombotic catheter occlusion. This model has the potential for application in clinical practice.

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外围置管中心血栓闭塞的模拟与建模

目的模拟导管血栓性闭塞，建立外周中心导管血栓性闭塞模型，为导管闭塞及闭塞后再通的研究提供框架。方法按照造模前的准备步骤，抽取无菌抗凝牛血液注射到PICC。随后夹住导管尖端，静置72小时。结果共制作140个导管模型，均出现血栓形成，导管内血栓生成成功率100%。其中118只模型在拔出注射器柱塞时无血液反流，并触发输液泵报警，导管闭塞建模成功率为84.29%。血栓性导管闭塞模型中，取下注射器柱塞无返血127例，发生率为90.71%，返血合并细血栓13例，发生率为9.29%。126个模型触发输液泵报警，发生率为90%，14个模型因导管尖端血栓溢出未触发报警，发生率为10%。输液泵报警法与注射器撤除法在诊断血栓性导管闭塞方面具有显著相关性。结论本研究中使用的血栓性导管闭塞建模方法是可靠的，生成的模型能够准确地模拟血栓性导管闭塞的基本特征。该模型具有临床应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.