Low Levels of Neutralizing Antibodies Against SARS-CoV-2 KP.3.1.1 and XEC in Serum From Seniors in May 2024

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-05-14 DOI:10.1111/irv.70102

Even Fossum, Elisabeth Lea Vikse, Anna Hayman Robertson, Asia-Sophia Wolf, Andreas Rohringer, Lill Trogstad, Siri Mjaaland, Olav Hungnes, Karoline Bragstad

引用次数: 0

Abstract

New immune evasive variants of SARS-CoV-2 may increase infections and hospitalizations in risk groups, such as the elderly. In this study, we evaluated neutralizing antibodies against KP.3.1.1 and XEC, virus variants that were either widely distributed or on the rise globally in the fall of 2024, in sera from a cohort of seniors aged 68–82 years collected in April/May 2024. Neutralizing responses were low against both KP.3.1.1 and XEC, also in XBB.1.5 boosted individuals and people with recent break-through infections, supporting the recommendation of an updated COVID-19 vaccine booster in this age group.

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2024年5月老年人血清中抗SARS-CoV-2 KP.3.1.1和XEC抗体水平低

新的免疫逃避型SARS-CoV-2可能会增加老年人等危险人群的感染和住院率。在这项研究中，我们在2024年4月/ 5月收集的一组68-82岁的老年人血清中评估了针对KP.3.1.1和XEC的中和抗体，这两种病毒变体在2024年秋季在全球广泛分布或呈上升趋势。对KP.3.1.1和XEC的中和反应都很低，对XBB.1.5增强的个体和最近出现突破性感染的人群也是如此，这支持了在这一年龄组使用更新的COVID-19疫苗增强剂的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.