The Role of Photobiomodulation Therapy in Reducing Stress-Induced Changes in the Hippocampus of Rats during Septoplasty Modeling

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2025-04-11 DOI:10.1134/S1607672924601033

V. N. Kotov, I. V. Kastyro, I. B. Ganshin, V. I. Popadyuk, S. G. Dragunova, O. S. Khodorovich, A. F. Kartasheva, M. I. Barannik, P. V. Sarygin

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Abstract

The aim of the study was to investigate the effect of photobiomodulation therapy (PBMT) on the amount of p53 in neurons of the pyramidal layer of the hippocampus after modeling septoplasty in rats. Materials and methods. Septoplasty was modeled in 48 Wistar rats. PBMT was administered to 24 rats in the early postoperative period for 2 to 6 days. Histological sections of the hippocampus were studied to determine p53-positive neurons on days 2, 4, and 6 after surgery in rats of both groups. Results. Compared with the control group (n = 5 rats), in both experimental groups there was an increase in the number of p53-positive neurons in the hippocampus, however, in the group where PBMT was performed in the early postoperative period after modeling septoplasty, the number of such neurons was lower, and in some subfields of the hippocampus on day 6 it even corresponded to the control group. Conclusions. The use of PBMT in the early postoperative period after modeling septoplasty helps to reduce stress-induced expression of the p53 protein in the pyramidal layer of the hippocampus in rats.

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光生物调节治疗在减少中隔成形术大鼠海马应激性变化中的作用

本研究旨在探讨光生物调节疗法（PBMT）对大鼠中隔成形术后海马锥体层神经元p53表达的影响。材料和方法。建立48只Wistar大鼠鼻中隔成形术模型。24只大鼠术后早期给予PBMT治疗2 ~ 6天。两组大鼠术后第2、4、6天海马组织切片检测p53阳性神经元。结果。与对照组（n = 5只大鼠）相比，两实验组海马中p53阳性神经元数量均有所增加，但在造模中隔成形术术后早期行PBMT组海马中p53阳性神经元数量较低，在第6天海马的部分亚区中p53阳性神经元数量甚至与对照组相当。结论。在造模鼻中隔成形术术后早期使用PBMT有助于减少应激诱导的大鼠海马锥体层p53蛋白的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.