Raden Bayu Indradi , Muhaimin Muhaimin , Melisa Intan Barliana , Alfi Khatib , Intan Timur Maisyarah , Dian Ayu Eka Pitaloka , Muhammad Fadhil Pratomo
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引用次数: 0
Abstract
Introduction
Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as Physalis angulata, need to be studied for their claimed efficacy to treat malaria.
Methods
In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of P. angulata to alleviate malaria, as confirmed by molecular docking.
Results
The result revealed that 25 compounds of P. angulata interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that withangulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4.
Conclusion
We predict that P. angulata alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria.
期刊介绍:
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.