Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2025-05-10 DOI:10.1016/j.bbalip.2025.159627

Calum Macrae , Damjan Lalović , Tom D. Bunney, Matilda Katan

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Abstract

A journey that started with the discovery of phospholipase C catalysed inositol-lipid hydrolysis as a receptor-controlled signalling event, culminated in defining molecular properties and roles of phosphoinositide-specific phospholipase C (PLC) families. Currently, there are six classical (13 isoforms) and one atypical (3 isoforms) family, expressed in a wide range of mammalian cells where they perform key functions in intracellular signal transduction. We here highlight recent advances in the PLC field, mostly resulting from studies of the PLCγ family members, PLCγ1 and PLCγ2. These new discoveries include elucidation of their structural and functional properties as well as their roles in physiology and disease development. We also illustrate the involvement of classical PLC families in control of cellular processes mediated not only by the PtdIns(4,5)P₂-derived second messengers, resulting from the PLC hydrolysis, but also by second messenger-independent consequences of PtdIns(4,5)P₂ hydrolysis. Presented examples are focused on regulation of ion channels by PtdIns(4,5)P₂.

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磷酸肌肽特异性磷脂酶C：在漫长旅程中的最新进展

从发现磷脂酶C催化肌醇脂水解作为受体控制的信号事件开始，最终确定了磷脂酶C （PLC）家族的分子特性和作用。目前，有6个经典亚型（13个）和1个非典型亚型（3个）家族，它们在广泛的哺乳动物细胞中表达，并在细胞内信号转导中发挥关键作用。我们在此重点介绍PLC领域的最新进展，主要来自PLCγ家族成员PLCγ1和PLCγ2的研究。这些新发现包括阐明它们的结构和功能特性以及它们在生理和疾病发展中的作用。我们还说明了经典PLC家族参与控制细胞过程，不仅由PLC水解产生的PtdIns(4,5)P2衍生的第二信使介导，而且还通过PtdIns(4,5)P2水解的第二信使独立的后果介导。所提出的例子主要集中在PtdIns(4,5)P2对离子通道的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.