Beyond convention: Construction of β-cyclodextrin-based shape-changing particles capable of light-responsive control and bioactivity application

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-05-12 DOI:10.1016/j.carbpol.2025.123733

Pu-Ying Qi , Li-Hong Shi , Zhi-Cheng Zheng , Fu-Mei Feng , Tai-Hong Zhang , Rong-Shuang Luo , Shuai Tan , A-Ling Tang , Hou-Yun Huang , Xiang Zhou , Hong-Mei Xiang , Li-Wei Liu , Song Yang

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引用次数: 0

Abstract

Environmentally triggered major phenomenological switching, including in shape, size, or curvature, is widely found in particles that occur in nature. We demonstrate a generic approach towards dynamically reconfiguring the shape of β-cyclodextrin(β-CD)-based particles to exploit the unique light-responsive behavior that can trigger “stimuli-responsive” controlled release of active molecules. In detail, solely enabled by their architecture, flakes and spheres comprising binary complexes formed between β-CD and antibacterial stilbenes molecule and/or azobenzene derivative underwent active reconfiguration, including reversible shape-shifting and bioactivity switching. Interestingly, these two particles (flakes and spheres) exhibited reversible and reproducible changes in their shape over repeated UV–vis irradiation cycles. The “stimuli-responsive” shape-shifting of nano-system regulated the switch of bioactivity in vitro and in vivo, inhibited biofilm formation, decreased bacterial motility, and disrupted the flagellar biosynthesis process. Overall, we developed a β-CD-based supramolecular assembly system related to the design and shape-adaptable properties of particles, providing a new paradigm on their prospective applications in nanomedicine/nanopesticide delivery.

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超越常规：基于β-环糊精的可光响应控制和生物活性应用的形状变化颗粒的构建

环境引发的主要现象学转换，包括形状、大小或曲率，广泛存在于自然界中发生的粒子中。我们展示了一种动态重新配置β-环糊精（β-CD）基颗粒形状的通用方法，以利用独特的光响应行为，触发“刺激响应”控制活性分子的释放。详细地说，由于它们的结构，由β-CD与抗菌二苯乙烯分子和/或偶氮苯衍生物之间形成的二元配合物组成的薄片和球体发生了积极的重构，包括可逆的形状变化和生物活性转换。有趣的是，这两种颗粒（片状和球形）在重复的UV-vis照射循环中表现出可逆和可重复的形状变化。纳米系统的“刺激响应型”变形调节了体外和体内生物活性的转换，抑制了生物膜的形成，降低了细菌的运动能力，破坏了鞭毛的生物合成过程。总的来说，我们开发了一种基于β- cd的超分子组装系统，该系统与颗粒的设计和形状适应性有关，为其在纳米药物/纳米农药递送中的潜在应用提供了新的范例。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.