Recent advancements in paper microfluidics for blood analysis and diagnostics

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-05-06 DOI:10.1016/j.trac.2025.118289

Zhiyuan Yang , Yafei Lou , Linan Sun , Siyu Chen , Miaosi Li , Zhuoxuan Lu , Liming Zhang , Rong Cao , Junfei Tian

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Abstract

Paper microfluidics has emerged as a transformative technology in blood analysis and diagnostics, offering a portable, cost-effective, and user-friendly alternative to traditional laboratory tests. This review discusses the progress in paper microfluidics for blood tests over the past five years, focusing on their potential to revolutionize point-of-care testing in resource-limited settings. After providing an overview of blood composition and the evolution of blood testing technologies, the review explores innovative advances in emerging microfluidic paper-based analytical devices for blood detection. It categorizes their applications based on the type of blood sample used and whether pretreatment techniques are required, enabling developers to efficiently identify suitable methodologies aligned with the intended sample state and accelerate the prototyping of devices. In addition, this review summarizes how paper substrate, is innovatively repurposed into auxiliary tools to enhance blood detection processes through its adaptability. Challenges in commercialization and promising directions for future development are also discussed.

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用于血液分析和诊断的纸微流体技术的最新进展

纸微流体已经成为血液分析和诊断领域的一项变革性技术，为传统的实验室测试提供了一种便携式、成本效益高、用户友好的替代方案。这篇综述讨论了过去五年来用于血液检测的纸质微流体技术的进展，重点讨论了它们在资源有限的环境下革新即时检测的潜力。在概述了血液成分和血液检测技术的发展之后，本文探讨了用于血液检测的新型微流控纸分析设备的创新进展。它根据所使用的血液样本类型和是否需要预处理技术对其应用进行分类，使开发人员能够有效地识别与预期样本状态一致的合适方法，并加速设备的原型设计。此外，本文综述了如何通过其适应性创新地将纸质基材重新利用为辅助工具以增强血液检测过程。还讨论了商业化面临的挑战和未来发展的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.