Therapeutic mechanisms of icariin in intervertebral disc degeneration: A critical narrative review

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-05-15 DOI:10.1016/j.bbrep.2025.102047

LiLun Zhong , ZhenWen Xu , YingJun Peng , SongPeng Li , An Liu , ZhiDong Lin

引用次数: 0

Abstract

Intervertebral disc degeneration (IDD), a primary cause of low back pain, involves complex pathological mechanisms. Current research emphasizes identifying strategies to mitigate degenerative processes and enhance intrinsic disc repair. Emerging evidence highlights the therapeutic potential of icariin (ICA) in promoting disc repair and delaying IDD progression. ICA exerts its effects through multiple mechanisms, including anti-inflammatory actions, oxidative stress mitigation, modulation of bone and collagen metabolism, and inhibition of ferroptosis and pyroptosis. This review synthesizes current research on ICA's therapeutic applications in IDD management.

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淫羊藿苷治疗椎间盘退变的机制：一个关键的叙事回顾

椎间盘退变（IDD）是引起腰痛的主要原因，涉及复杂的病理机制。目前的研究强调确定减轻退变过程和增强椎间盘内禀修复的策略。新出现的证据强调淫羊藿苷（ICA）在促进椎间盘修复和延缓IDD进展方面的治疗潜力。ICA通过多种机制发挥其作用，包括抗炎作用、氧化应激缓解、调节骨和胶原代谢、抑制铁下垂和焦亡。本文综述了ICA在IDD治疗中的应用研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.