The effect of chronic pain on memory: A systematic review and meta-analysis exploring the impact of nociceptive, neuropathic and nociplastic pain

IF 2.2 3区心理学 Q3 NEUROSCIENCES

Brain and Cognition Pub Date : 2025-05-14 DOI:10.1016/j.bandc.2025.106305

Kate Kelly , Emily Keohane , Gemma Davy

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引用次数: 0

Abstract

Chronic pain is becoming increasingly prevalent in modern society. Much research to date has focused on the physical symptoms of pain associated with various conditions, yet living with chronic pain is also known to impact an individual’s cognition. Within cognition, memory is particularly vulnerable to outside factors, yet our understanding of the impact of chronic pain on memory is inconclusive. This systematic review and meta-analysis examined the association between chronic pain type and memory performance. Chronic pain samples were classified as nociceptive, neuropathic or nociplastic and were compared to healthy controls. Studies were sourced from Embase, Web of Science, MEDLINE, PubMed, PsycINFO, Scopus and CINAHL databases between December 2023 and July 2024. A total of 15 good – strong studies with 1865 participants were included (106 who experienced chronic nociceptive pain, 315 who experienced chronic neuropathic pain, 589 who experienced chronic nociplastic pain and 855 healthy controls). Results indicated that individuals with nociceptive and nociplastic pain had impaired short-term and long-term memory performance compared to healthy controls. The same was not true for individuals with neuropathic pain. These findings demonstrate that the type of pain one experiences impacts memory performance. This has profound implications both clinically and with regard to research and offers a new lens for how we can consider chronic pain when trying to understand the impact on cognition.

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慢性疼痛对记忆的影响：一项系统回顾和荟萃分析，探讨伤害性、神经性和伤害性疼痛的影响

慢性疼痛在现代社会变得越来越普遍。迄今为止，许多研究都集中在与各种疾病相关的疼痛的身体症状上，然而慢性疼痛也会影响个人的认知。在认知中，记忆特别容易受到外界因素的影响，但我们对慢性疼痛对记忆的影响的理解尚无定论。这项系统回顾和荟萃分析研究了慢性疼痛类型和记忆表现之间的关系。慢性疼痛样本被分类为伤害性、神经性或伤害性，并与健康对照进行比较。研究来源于Embase、Web of Science、MEDLINE、PubMed、PsycINFO、Scopus和CINAHL数据库，时间为2023年12月至2024年7月。共纳入15项强效研究，共1865名参与者（106名经历过慢性伤害性疼痛，315名经历过慢性神经性疼痛，589名经历过慢性伤害性疼痛，855名健康对照）。结果表明，与健康对照相比，患有伤害性和伤害性疼痛的个体的短期和长期记忆表现受损。对于患有神经性疼痛的人来说，情况并非如此。这些发现表明，一个人经历的疼痛类型会影响记忆表现。这对临床和研究都有深远的影响，并为我们在试图理解慢性疼痛对认知的影响时如何考虑慢性疼痛提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Cognition 医学-神经科学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.