Menopause is associated with a reduction in glomerular filtration rate, independent of body composition and metabolic syndrome

IF 3.9 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2025-05-09 DOI:10.1016/j.maturitas.2025.108595

Alessandro Leone , Francesca Menichetti , Federica Sileo , Silvia Gallosti , Ramona De Amicis , Andrea Foppiani , Simona Bertoli , Alberto Battezzati

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引用次数: 0

Abstract

Objectives

This study examines the relationship between menopause and glomerular filtration rate (GFR), independent of body composition and metabolic profile, both known risk factors for GFR decline.

Study design

Cross-sectional study involving 3918 women aged 40–55 years.

Main outcome measures

Participants provided information about medical history, menopausal status, and current medication use. Participants underwent nutritional and anthropometric assessments. Blood samples were collected to measure biochemical parameters. Menopause was defined as no menstrual cycle for 12 months or more. GFR was estimated using the EPI-CKD formula, and metabolic syndrome was identified using harmonized criteria. Premenopausal and postmenopausal women were matched by age, body composition, and metabolic syndrome factors to assess the menopause–GFR association.

Results

Postmenopausal women exhibited higher fat mass, lower fat-free mass, and reduced GFR compared with premenopausal women. They also had higher rates of hypertension, impaired fasting glucose, and metabolic syndrome. After matching for age, fat mass index, fat-free mass index, and components of the metabolic syndrome, menopause was independently associated with a GFR reduction of 2.32 ml/min/1.73m² (95 % CI: −3.81, −0.83). Additionally, menopause was linked to a 51 % higher risk of GFR <90 ml/min/1.73m² (OR = 1.51; 95 % CI 1.12, 2.02).

Conclusions

Menopause represents an independent risk factor for GFR decline, beyond the effects related to body composition and metabolic risk factors.

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绝经与肾小球滤过率降低有关，与身体成分和代谢综合征无关

目的：本研究探讨绝经与肾小球滤过率（GFR）之间的关系，独立于身体成分和代谢谱，两者都是已知的GFR下降的危险因素。研究设计横断面研究涉及3918名40-55岁的女性。主要结果测量：参与者提供了病史、绝经状态和当前用药情况的信息。参与者接受了营养和人体测量评估。采集血样测定生化指标。绝经被定义为12个月或更长时间没有月经周期。使用EPI-CKD公式估计GFR，使用统一标准确定代谢综合征。绝经前和绝经后妇女按年龄、身体组成和代谢综合征因素进行匹配，以评估绝经与gfr的关系。结果与绝经前妇女相比，绝经后妇女表现出更高的脂肪量、更低的无脂量和更低的GFR。他们患高血压、空腹血糖受损和代谢综合征的几率也更高。在匹配年龄、脂肪质量指数、无脂质量指数和代谢综合征成分后，绝经与GFR降低2.32 ml/min/1.73m2独立相关（95% CI:−3.81,−0.83）。此外，绝经期与GFR （90 ml/min/1.73m2）风险增加51%相关(OR = 1.51；95% ci 1.12, 2.02)。结论绝经是GFR下降的独立危险因素，超出了机体成分和代谢危险因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life