Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan, 2022

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-05-13 DOI:10.3201/eid3106.241315

Kengo Tokunaga, Emiko Rimbara, Toshihisa Tsukadaira, Katsuhiro Mabe, Koji Yahara, Hidekazu Suzuki, Tadashi Shimoyama, Mitsushige Sugimoto, Tadayoshi Okimoto, Hidenori Matsui, Masato Suzuki, Keigo Shibayama, Hiroyoshi Ota, Kazunari Murakami, Mototsugu Kato

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Abstract

To evaluate non–H. pylori Helicobacter (NHPH) infections in Japan, we enrolled 673 consecutive patients who underwent gastric endoscopy during annual medical checkups at 4 hospitals during May–August 2022. We collected intragastric fluid and serum samples to detect NHPH infection by PCR and serologic tests. The prevalence of NHPH was 3% (20/673); 70% (14/20) of patients were infected with H. suis and 30% (6/20) with non–H. suis NHPH species. All 14 H. suis–infected patients were men and had a history of pork offal ingestion. Among non–H. suis NHPH-infected patients, 50% (3/6) owned pet cats, whereas only 22% (145/667) of other patients owned cats. Endoscopic evaluation revealed marbled crack-like gastritis was present in 93% (13/14) of H. suis–infected patients, a significantly higher prevalence than for H. pylori–infected (28.6%) and H. pylori eradication therapy (27.6%) groups. Pork offal ingestion and having pet cats increase risk for Helicobacter spp. infections.

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非h型肝炎的前瞻性多中心监测。体检期间幽门螺杆菌感染，日本，2022年

求非h的值。在日本幽门螺杆菌（NHPH）感染的研究中，我们招募了673名连续的患者，他们在2022年5月至8月期间在4家医院的年度体检期间接受了胃内窥镜检查。我们收集胃液和血清样本，采用PCR和血清学检测NHPH感染。NHPH患病率为3% (20/673)；70%（14/20）的患者感染猪嗜血杆菌，30%（6/20）的患者感染非猪嗜血杆菌。瑞士NHPH物种。14例猪嗜血杆菌感染患者均为男性，均有猪内脏摄入史。non-H之一。在瑞士感染nhph的患者中，50%（3/6）有宠物猫，而其他患者中只有22%（145/667）有宠物猫。内镜检查显示，93%（13/14）的猪链球菌感染患者存在大理石裂纹样胃炎，明显高于幽门螺杆菌感染组（28.6%）和幽门螺杆菌根除治疗组（27.6%）。食用猪肉内脏和养宠物猫会增加感染幽门螺杆菌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.