Mercapto-β-cyclodextrin grafting uniform spherical covalent organic frameworks for enantioseparation in liquid chromatography

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-05-14 DOI:10.1016/j.aca.2025.344186

Huizhen Ni, Wentao Xu, Linna Xu, Songlin Chen, Junchao Zhu, Shengqiang Tong

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Abstract

Despite the extensive development of covalent organic frameworks (COFs) as stationary phases for chromatography, the majority of COF-based stationary phases require application by bonding or coating on silica gel due to their irregular morphology, nanoscale particle size and broad particle size distribution, which limits the utilization of COFs in liquid chromatography. To take full advantage of COFs, we synthesized size-controllable spherical COFs (SCOFs) as stationary phases further functionalized by mercapto-β-cyclodextrin (SCOFs@CD). The direct-packed SCOFs-1.5μm column achieved separations of small molecules including monosubstituted aromatics, polycyclic aromatic hydrocarbons, and alkylbenzenes, which showed better column efficiency than the SCOFs-2.0μm column. Furthermore, the SCOFs-1.5μm@CD successfully separated dansulfonyl derivatized branched-chain amino acids (DNS-BCAAs) in HILIC mode. This research expanded the application of SCOFs stationary phases and demonstrated their significant potential in liquid chromatography.

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巯基-β-环糊精接枝均匀球形共价有机框架在液相色谱对映体分离中的应用

尽管共价有机框架（COFs）作为色谱的固定相得到了广泛的发展，但由于其不规则的形态、纳米级的粒径和广泛的粒径分布，大多数COFs基固定相需要通过粘合或涂覆在硅胶上应用，这限制了COFs在液相色谱中的应用。为了充分利用COFs，我们合成了粒径可控的球形COFs （SCOFs）作为固定相，并通过巯基-β-环糊精（SCOFs@CD）进一步功能化。直接填充的SCOFs-1.5μm柱对单取代芳烃、多环芳烃、烷基苯等小分子化合物的分离效果优于SCOFs-2.0μm柱。此外，SCOFs-1.5μm@CD在HILIC模式下成功分离了丹磺酰衍生支链氨基酸（DNS-BCAAs）。本研究拓展了SCOFs固定相在液相色谱中的应用，展示了SCOFs固定相在液相色谱中的巨大潜力。

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.