Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair.

IF 15.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
ACS Nano Pub Date : 2025-05-13 DOI:10.1021/acsnano.4c18874
Xiaohui Ju,Eliška Javorková,Jan Michalička,Martin Pumera
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引用次数: 0

Abstract

Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.
单原子胶体纳米机器人增强干细胞治疗角膜损伤修复。
由于细胞的长期存活问题,使用间充质干细胞治疗角膜修复面临挑战。在这里,我们设计了氧化铈与金单原子纳米机器人(CeSAN-bots),用于与干细胞协同治疗角膜损伤。在葡萄糖的驱动下,由于金和氧化铈催化的级联反应,cesan -bot表现出增强的扩散和主动运动。与被动摄取相比,cesan机器人在细胞摄取间充质干细胞方面的效率提高了两倍。cesan机器人具有内在的抗氧化和免疫调节特性,促进角膜再生。在小鼠角膜碱烧伤模型中的验证表明,当干细胞与CeSAN-bots结合时,角膜清晰度恢复得到改善。这项工作提出了一种开发葡萄糖驱动的、无酶的、基于单原子的超小型纳米机器人的策略,该机器人在多种生物环境下的靶向细胞内递送中具有前景。
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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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