Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-05-14 DOI:10.1111/cns.70427

Yanqing He, Kang Xie, Kang Yang, Nianhua Wang, Longbo Zhang

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Abstract

Background

Neurodevelopment is a multifaceted and tightly regulated process essential for the formation, maturation, and functional specialization of the nervous system. It spans critical stages, including cellular proliferation, differentiation, migration, synaptogenesis, and synaptic pruning, which collectively establish the foundation for cognitive, behavioral, and emotional functions. Metabolism serves as a cornerstone for neurodevelopment, providing the energy and substrates necessary for biosynthesis, signaling, and cellular activities.

Results

Key metabolic pathways, including glycolysis, lipid metabolism, and amino acid metabolism, support processes such as cell proliferation, myelination, and neurotransmitter synthesis. Crucial signaling pathways, such as insulin, mTOR, and AMPK, further regulate neuronal growth, synaptic plasticity, and energy homeostasis. Dysregulation of these metabolic processes is linked to a spectrum of neurodevelopmental disorders, including autism spectrum disorders (ASDs), intellectual disabilities, and epilepsy.

Conclusions

This review investigates the intricate interplay between metabolic processes and neurodevelopment, elucidating the molecular mechanisms that govern brain development and the pathogenesis of neurodevelopmental disorders. Additionally, it highlights potential avenues for the development of innovative strategies aimed at enhancing brain health and function.

Abstract Image

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揭示健康和疾病中代谢和神经发育之间的相互作用

神经发育是神经系统形成、成熟和功能特化的一个多方面的、受到严格调控的过程。它跨越关键阶段，包括细胞增殖、分化、迁移、突触发生和突触修剪，这些共同建立了认知、行为和情感功能的基础。代谢是神经发育的基石，为生物合成、信号传导和细胞活动提供必要的能量和底物。主要代谢途径包括糖酵解、脂质代谢和氨基酸代谢，支持细胞增殖、髓鞘形成和神经递质合成等过程。关键信号通路，如胰岛素、mTOR和AMPK，进一步调节神经元生长、突触可塑性和能量稳态。这些代谢过程的失调与一系列神经发育障碍有关，包括自闭症谱系障碍（ASDs）、智力残疾和癫痫。本文综述了代谢过程与神经发育之间复杂的相互作用，阐明了脑发育的分子机制和神经发育障碍的发病机制。此外，它还强调了开发旨在增强大脑健康和功能的创新战略的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.