Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance (Adv. Therap. 5/2025)

IF 3.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2025-05-14 DOI:10.1002/adtp.202570011

Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein, Karel D. Klika, Christian Kleist, Julia Werner, Cornelius Domhan, Mara Bingel, Anna Müller, Marvin Rausch, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Marcus Koch, Markus Bischoff, Tanja Schneider, Rolf Müller, Jennifer Herrmann, Walter Mier, Philipp Uhl

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Abstract

Conjugation of daptomycin to polycationic peptides improves its efficacy against daptomycin-resistant S. aureus and vancomycin-resistant E. faecium with reduced daptomycin sensitivity. This approach of modifying existing antibiotics via peptide conjugation represents a promising strategy to overcome antibiotic resistance and enhance drug activity. More details can be found in article 2400473 by Jennifer Herrmann, Philipp Uhl, and co-workers.

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抗生素-多阳离子肽偶联作为克服达托霉素耐药的有效策略（ad . therapy . 5/2025）

达托霉素与多阳离子多肽偶联可提高其对耐达托霉素金黄色葡萄球菌和耐万古霉素粪肠杆菌的疗效，但降低了达托霉素的敏感性。这种通过肽偶联修饰现有抗生素的方法代表了克服抗生素耐药性和增强药物活性的有希望的策略。更多细节可以在Jennifer Herrmann， Philipp Uhl及其同事的文章2400473中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130