Skin Wound Healing Following Injecting Hyaluronic Acid Rejuvenating Complex, Polycaprolactone, or Combination Therapy: An Experimental Study

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-05-14 DOI:10.1111/jocd.70221

Noury Adel, Nenad Stankovic, Gerardo Cervantes, Amira Gindi, Lamiaa Mohamed Shawky

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引用次数: 0

Abstract

Purpose

This study aimed to investigate the effects of hyaluronic acid rejuvenating complex, polycaprolactone, and their combination on skin wound healing, assessing their potential to accelerate tissue regeneration and optimize healing outcomes.

Materials and Methods

Forty eight Wistar Albino rats were randomly divided into four groups. Group 1 received hyaluronic acid rejuvenating complex injection, Group 2 received polycaprolactone injection, and Group 3 received a combination of both. Group 4 served as the control, undergoing incision without intervention. Skin biopsies were collected at baseline, day 7, and day 14 postincision. Wound healing was evaluated histologically using hematoxylin and eosin (H&E) and Masson's trichrome staining, focusing on epithelial thickness, collagen synthesis, and inflammatory cell infiltration.

Results

The combination therapy group (Group 3) exhibited the most pronounced wound healing response, demonstrating significantly accelerated re-epithelialization, enhanced collagen deposition, and well-structured granulation tissue by days 7 and 14. Additionally, inflammatory cell infiltration was markedly reduced, indicating a faster transition from the inflammatory to the proliferative phase. Compared to single-agent treatments, the combined approach resulted in superior tissue remodeling and a more efficient healing process.

Conclusion

The dual administration of hyaluronic acid rejuvenating complex and polycaprolactone offers a synergistic effect, significantly enhancing skin wound healing compared to monotherapies. These findings highlight the potential of combination therapy as a promising strategy for improving wound repair and tissue regeneration in aesthetic and regenerative dermatology.

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注射透明质酸复合体、聚己内酯或联合治疗后皮肤伤口愈合：一项实验研究

本研究旨在探讨透明质酸复合体、聚己内酯及其组合对皮肤创面愈合的影响，评估其促进组织再生和优化愈合效果的潜力。材料与方法48只Wistar白化大鼠随机分为4组。组1给予透明质酸复合体注射，组2给予聚己内酯注射，组3给予两者联合。第4组为对照组，不干预切开。在基线、切口后第7天和第14天采集皮肤活检。使用苏木精和伊红（H&；E）和马松三色染色对伤口愈合进行组织学评估，重点关注上皮厚度、胶原合成和炎症细胞浸润。结果联合治疗组（第3组）伤口愈合反应最明显，第7天和第14天伤口再上皮化明显加快，胶原沉积增强，肉芽组织结构良好。此外，炎症细胞浸润明显减少，表明炎症期向增殖期的过渡速度更快。与单一药物治疗相比，联合治疗的结果是更好的组织重塑和更有效的愈合过程。结论透明质酸复合体与聚己内酯双给药具有协同作用，与单给药相比，能显著促进皮肤创面愈合。这些发现强调了联合治疗的潜力，作为一种有前途的策略，以改善伤口修复和组织再生美学和再生皮肤病学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.