Total synthesis enabled structure revision of sesquiterpenoids

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-08 DOI:10.1039/d5ob00282f

Keke Guo , Linhao Xia , Hongxi Xu , Changwu Zheng

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引用次数: 0

Abstract

Sesquiterpenoids have attracted the attention of chemists and biologists due to their unique structures and potential biological activities. Because of the complexity of their structures, many sesquiterpenoids have not been accurately assigned in the initial isolation and identification process, which caused obstacles to following research. In this mini-review, we systematically summarized the structural revision of sesquiterpenoids based on the total synthesis reported from 2016 to 2024. The discussion is categorized into four aspects based on different strategies of structural revision: (1) re-evaluation based on NMR analysis or computational simulations; (2) discrepancy in optical rotation values; (3) confirmation via X-ray crystallography; (4) synthesis and comparison of optical isomers. On the one hand, the review fills the gap of structural revision of sesquiterpenoids based on total synthesis. On the other hand, it also provides synthetic chemists with critical insights into the powerful applications and distinct perspectives of total synthesis approaches in the structural elucidation and revision of natural products.

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全合成使倍半萜类化合物的结构得到修正

倍半萜类化合物因其独特的结构和潜在的生物活性而受到化学家和生物学家的关注。由于其结构的复杂性，许多倍半萜类化合物在最初的分离和鉴定过程中没有被准确地分配，这给后续的研究带来了障碍。在这篇小型综述中，我们系统地总结了2016年至2024年报道的倍半萜类化合物的结构修订。根据不同的结构修正策略，讨论分为四个方面：(1)基于核磁共振分析或计算模拟的重新评估；(2)旋光值差异；(3) x射线晶体学确认；(4)光学异构体的合成与比较。一方面，填补了基于全合成的倍半萜类化合物结构修正的空白。另一方面，它也为合成化学家提供了对全合成方法在天然产物结构解析和修订中的强大应用和独特观点的关键见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.