Microthermofluidic systems: From conceptualization to implementation for point of care diagnostic applications

IF 4.1 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-05-11 DOI:10.1016/j.sna.2025.116689

Madhusudan B. Kulkarni , Sanket Goel

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Abstract

In recent years, there has been diligent expansion with emerging technological trends in developing microthermofluidic systems. Basically, a microthermofluidic system originates from integrating microfluidic technology and a thermal management system onto a single platform for accurate and stable heat transfer within the microchannel for several biomedical, pharmaceutical, and biochemical applications. In microfluidic devices, temperature is anelementary parameter. Still, it is sporadically ignored because of the non-uniform distribution of heat, high thermal dissipation, and the challenges associated with conventional heaters being able to be integrated into a microfluidic channel. The existing heaters are large, consume more power, are hard to incorporate advanced technological trends and fail to be used for point-of-care testing. Herein, the microthermofluidic system plays an incredible role in a microscale environment that manipulates a minimal fluid volume and offers the desired temperature uniformly on-chip. The microthermofluidic system can be accomplished for countless universal applications in healthcare, food processing, agriculture, chemical engineering, drug delivery, and clinical settings. This article comprehensively discusses the evolution and role of microthermofluidic systems, the significance of material selection, geometric design with appropriate optimization, and different fabrication tools involved in developing integrated microthermofluidic systems that undergo numerous biological and biochemical analyses. Further, the article sheds light on recent advances in microthermofluidic systems that have been implemented and are used for several applications. It also describes miniaturized thermoelectric devices.

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微热流体系统：从概念到实现护理点诊断应用

近年来，微热流控系统的发展不断扩大，出现了新的技术趋势。基本上，微热流控系统起源于将微流控技术和热管理系统集成到单个平台上，用于几种生物医学，制药和生化应用的微通道内精确和稳定的传热。在微流控装置中，温度是一个基本参数。然而，由于热量分布不均匀、热耗散高，以及传统加热器能够集成到微流体通道中的挑战，它偶尔被忽视。现有的加热器体积大，耗电多，难以融入先进的技术趋势，无法用于即时检测。在这里，微热流体系统在微尺度环境中发挥着令人难以置信的作用，它可以操纵最小的流体体积，并在芯片上提供所需的均匀温度。微热流体系统可以在医疗保健、食品加工、农业、化学工程、药物输送和临床环境中实现无数的普遍应用。本文全面讨论了微热流控系统的演变和作用，材料选择的意义，适当优化的几何设计，以及开发集成微热流控系统所涉及的不同制造工具，这些系统经过了大量的生物和生化分析。此外，文章阐明了微热流体系统的最新进展，这些系统已经实现并用于几种应用。它还描述了小型化的热电装置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...