Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-05-12 DOI:10.1016/j.bioactmat.2025.05.002

Sathishkumar Gnanasekar , Xiaodong He , Bruna E. Nagay , Kun Xu , Xi Rao , Shun Duan , Selvakumar Murugesan , Valentim A.R. Barão , En-Tang Kang , Liqun Xu

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引用次数: 0

Abstract

The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static, dynamic, and active coating techniques were established to tackle implant-associated infections (IAIs). However, the existing implant coating methods often confront issues with poor universality for different substrates, adaptability, stability, and the emergence of multi-drug resistance (MDR). The miraculous two-dimensional (2D) MXenes with outstanding multimodal bactericidal effects have been spotted as promising non-antibiotic implant surface coating additives for superior antibiofilm and osseointegration properties. This review systematically assesses the recent progress of antibacterial MXenes and their revolutionary usage to prevent peri-implantitis. We specifically sought to disclose the various forms of MXenes, such as composites, heterojunctions (HJs), and functional biomaterials used in combatting MDR and non-MDR bacterial pathogens by adopting therapeutic ventures such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT). In addition, we outlined the extension of MXene antibacterial systems for orthopedic and dental implant surface engineering to improve their longevity and safety. A thorough understanding of antibacterial MXenes synthesis, surface modification strategies, and biocompatible functional properties was deliberated to facilitate the construction of innovative coatings. Lastly, some viewpoints on the current limitations and key considerations for the future concept design of MXenes-coated implants were contemplated constructively to promote clinical outcomes.

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抗菌MXenes：一个新兴的非抗生素范例，用于骨科和牙科种植体的表面工程

浮游细菌在植入物表面的定植是医疗领域的一个严重问题，因为全世界与感染有关的死亡率不断上升，而且财政困难。各种静态、动态和活性涂层技术被建立来解决种植体相关感染（IAIs）。然而，现有的种植体包衣方法往往面临着对不同基质的通用性差、适应性差、稳定性差以及出现多药耐药（MDR）等问题。神奇的二维（2D） MXenes具有出色的多模态杀菌效果，已被发现作为有前途的非抗生素种植体表面涂层添加剂，具有良好的抗生素膜和骨整合性能。本文系统地综述了抗菌MXenes的最新进展及其在预防种植体周围炎中的革命性应用。我们特别寻求揭示各种形式的MXenes，如复合材料、异质结（HJs）和功能性生物材料，通过采用光热疗法（PTT）、光动力疗法（PDT）、化学动力疗法（CDT）和声动力疗法（SDT）等治疗企业，用于对抗MDR和非MDR细菌病原体。此外，我们概述了MXene抗菌系统在骨科和牙科种植体表面工程中的扩展，以提高其使用寿命和安全性。深入了解抗菌MXenes的合成、表面改性策略和生物相容性功能特性，以促进创新涂层的构建。最后，对目前的局限性和未来mxenes涂层植入物概念设计的关键因素进行了建设性的思考，以促进临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.