Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-05-11 DOI:10.1016/j.bioactmat.2025.04.037

Bruna E. Nagay , Samuel S. Malheiros , Maria H.R. Borges , Conrado Aparicio , Jeroen J.J.P. van den Beucken , Valentim A.R. Barão

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引用次数: 0

Abstract

Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic mechanisms, are emerging as promising solutions for activating targeted antimicrobial responses. While extensive reviews have provided insight into photocatalysis and its medical and environmental applications, limited focus has been given to solutions specifically tailored for implant contexts. The recent introduction of photocatalysis in the implant field, particularly visible-light-triggered photocatalytic coatings, represents a versatile approach to managing infections. These coatings offer on-demand reactive oxygen species generation, delivering antibacterial effects against a range of pathogens. Hence, this comprehensive review aims to summarize the latest advancements in design principles, physicochemical modifications, and surface optimizations, along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity. Moreover, through a systematic search, this review discusses the current state-of-the-art regarding the antimicrobial efficacy of these biomaterials and the key factors influencing their performance, including microorganism type, photocatalyst properties, light source and intensity, and exposure time. Finally, it provides an in-depth discussion of current challenges, future directions, and regulatory considerations targeting biofilm-related implant treatments, offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.

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抗植入物相关感染的可见光活化光催化涂层研究进展：从机制到转化路线图

生物医学和牙科植入物改善了医疗保健，但同时也增加了感染的风险。智能生物材料的创新，特别是那些通过光催化机制响应光刺激的创新，正在成为激活靶向抗菌反应的有希望的解决方案。虽然广泛的综述提供了对光催化及其医疗和环境应用的见解，但对专门为植入物量身定制的解决方案的关注有限。最近在种植体领域引入了光催化技术，特别是可见光触发的光催化涂层，代表了一种控制感染的通用方法。这些涂层提供按需活性氧生成，提供对一系列病原体的抗菌效果。因此，本综述旨在总结设计原理、物理化学修饰和表面优化方面的最新进展，以及实现可见光触发光催化抗菌活性的新研究概念。此外，通过系统的检索，本文综述了这些生物材料的抗菌效果的最新研究进展以及影响其性能的关键因素，包括微生物类型、光催化剂性能、光源和强度以及曝光时间。最后，深入讨论了生物膜相关种植体治疗的当前挑战、未来方向和监管考虑，为未来临床应用多功能光催化涂层在种植体治疗中的应用提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.