Synthesis of novel vesicle-like polysaccharide derivative for boosting water lubrication of silicon-based devices

IF 6.1 1区工程技术 Q1 ENGINEERING, MECHANICAL

Tribology International Pub Date : 2025-05-12 DOI:10.1016/j.triboint.2025.110796

Tao Li , Min Zhang , Renjie Li , Yunsong Kong , Xiaoduo Zhao , Le Ji , Weiyi Zhao , Bin Li , Shuanhong Ma

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引用次数: 0

Abstract

To minimize friction when silicone-based medical devices interact with soft tissues, coating their hydrophobic surfaces with lubricants has become a widely adopted method. In this study, a vesicle-like polysaccharide derivative biolubricant (HPC-PSBMA) is synthesized by combining hydrophilic monomers with hydroxypropyl cellulose (HPC) as the main chain. HPC-PSBMA exhibits good dispersibility in water, and it can be adsorbed onto the surface of silicone rubber. By integrating molecular dynamics simulations with experimental data, the adsorption and film-forming mechanisms are uncovered. Furthermore, HPC-PSBMA showed a lower coefficient of friction (COF∼0.02) on the surface of urinary catheters when compared with commercially available lubricants (COF∼0.05). Consequently, this work offers a novel approach to improving surface lubrication of hydrophobic medical devices with broad potential applications.

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促进硅基器件水润滑的新型囊泡类多糖衍生物的合成

为了最大限度地减少硅基医疗器械与软组织相互作用时的摩擦，在其疏水表面涂上润滑剂已成为一种广泛采用的方法。本研究以羟丙基纤维素（HPC）为主链为亲水单体，合成了一种囊泡状多糖衍生物生物润滑剂（HPC- psbma）。HPC-PSBMA在水中具有良好的分散性，可吸附在硅橡胶表面。通过将分子动力学模拟与实验数据相结合，揭示了吸附和成膜机理。此外，与市售润滑剂（COF ~ 0.05）相比，HPC-PSBMA在导尿管表面的摩擦系数（COF ~ 0.02）更低。因此，这项工作为改善疏水医疗设备的表面润滑提供了一种具有广泛潜在应用前景的新方法。

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来源期刊

Tribology International 工程技术-工程：机械

CiteScore

10.10

自引率

16.10%

发文量

627

审稿时长

35 days

期刊介绍： Tribology is the science of rubbing surfaces and contributes to every facet of our everyday life, from live cell friction to engine lubrication and seismology. As such tribology is truly multidisciplinary and this extraordinary breadth of scientific interest is reflected in the scope of Tribology International. Tribology International seeks to publish original research papers of the highest scientific quality to provide an archival resource for scientists from all backgrounds. Written contributions are invited reporting experimental and modelling studies both in established areas of tribology and emerging fields. Scientific topics include the physics or chemistry of tribo-surfaces, bio-tribology, surface engineering and materials, contact mechanics, nano-tribology, lubricants and hydrodynamic lubrication.