Ecotoxicological impact of the fungicide tebuconazole on fish: a historical review, global trends and challenges

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2025-05-04 DOI:10.1016/j.aquatox.2025.107398

Bianca Leite Carnib , Felipe Cirqueira , Jerusa Maria de Oliveira , Thiago Lopes Rocha

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引用次数: 0

Abstract

Tebuconazole (TBZ) is a triazole fungicide broadly used to control fungal diseases in agricultural crops, fruit-bearing plants and forestry plantations. However, its increasing use and release into aquatic environments has raised concerns about its hazardous effects on the health of fish. Thus, the aim of the present study was to review the scientific literature on the ecotoxicological effects of TBZ and TBZ-based commercial formulations on fish. Historical review data (publication year and geographical distribution), TBZ type, experimental design, fish species, habitat, life stage, tissue/organ, lethal concentration (LC₅₀), concentration and exposure time, biomarkers and effects were compiled and critically analyzed. Studies were mainly conducted with freshwater species at adult and larval stages, whereas no data were find for marine fish species. Zebrafish, (Danio rerio) was the most assessed species. Both TBZ and TBZ-based commercial formulations induced oxidative stress, endocrine disruption, neurotoxicity, genotoxicity, histopathologies, behavior impairments and mortality on fish. TBZ can induce synergistic and antagonistic effects on fish when it is combined to other pesticides. Overall, the current study has shown the potential hazardous effects of TBZ and TBZ-based commercial formulations on the health of fish.

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杀菌剂苯唑唑对鱼类的生态毒理学影响：历史回顾、全球趋势和挑战

戊康唑（Tebuconazole， TBZ）是一种三唑类杀菌剂，广泛用于防治农作物、果树和林业人工林的真菌病害。然而，其越来越多的使用和释放到水生环境中，引起了人们对其对鱼类健康有害影响的关注。因此，本研究的目的是回顾有关TBZ和基于TBZ的商业配方对鱼类生态毒理学影响的科学文献。对历史综述资料（出版年份和地理分布）、TBZ类型、实验设计、鱼类种类、栖息地、生命阶段、组织/器官、致死浓度（LC50）、浓度和暴露时间、生物标志物和效应进行整理和批判性分析。研究主要针对淡水鱼类的成鱼和幼虫阶段，而没有发现海洋鱼类的数据。斑马鱼（Danio rerio）是评估最多的物种。TBZ和以TBZ为基础的商业配方均可引起鱼的氧化应激、内分泌紊乱、神经毒性、遗传毒性、组织病理学、行为障碍和死亡。TBZ与其他农药联用时，对鱼类具有增效和拮抗作用。总的来说，目前的研究表明，太苯三甲酸乙酯和基于太苯三甲酸乙酯的商业配方对鱼类健康有潜在的有害影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.