Comparative study of bone mineral density using quantitative computed tomography to establish a local population reference standard and comparison with existing osteoporosis Standards: Insights from south India

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-05-09 DOI:10.1016/j.cegh.2025.102030

Hemanth Kumar Deevi , Sanjay Kini B , Manjula A , Prakashini Koteshwara

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引用次数: 0

Abstract

Background

Early identification of reduced bone mineral density (BMD) and providing appropriate measures depending on BMD values, lead to early prevention and treatment of osteoporosis-related complications effectively. Quantification of osteoporosis can also be done by quantitative computed tomography (qCT). The present study was conducted to derive a reference standard BMD using phantomless qCT software for our local population of South India.

Methods

A hospital-based cross-sectional study was conducted among patients >20 years of age who were undergoing a CT study which included T12, L1 & L2 vertebrae and were free of obvious bone pathology. The axial CT series was used to calculate the BMD. Using the average BMD, we obtained from the patients in the age group of 20–39 years, an average and a standard deviation were calculated. Later we recalculated the T scores for patients across all age groups using cross-tabulations to identify how many people were under the osteoporosis group in each of the standards [US standards ie; the University of California, San Francisco (UCSF) standards, World Health Organization (WHO) standards and locally derived standards).

Results

The mean BMD for the age group of 20–39 years were obtained for both males and females as 149.4 mg/cc² and 152.5 mg/cc² respectively. Based on the bone attenuation in CT we found that attenuation >120 Hounsfield units (HU) did not have any osteoporosis and attenuation >200 HU did not have any osteopenia according to our reference standards. Similarly, when we considered the values of UCSF standards we found that attenuation >180 HU did not have any osteoporosis and attenuation >240 HU did not have any osteopenia whereas according to WHO standards attenuation >130 HU did not have any osteoporosis and attenuation >210 HU did not have any osteopenia.

Conclusion

Given the enormous patient volume of body CT scanning currently performed in older adults for a wide variety of clinical indications, this represents a unique opportunity to expand osteoporosis screening.

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利用定量计算机断层扫描建立当地人口参考标准的骨密度比较研究，并与现有骨质疏松症标准进行比较：来自南印度的见解

背景：准确识别骨密度降低，并根据骨密度值提供适当的措施，可有效地早期预防和治疗骨质疏松相关并发症。骨质疏松症的定量也可以通过定量计算机断层扫描（qCT）来完成。本研究是利用无影qCT软件为南印度当地人口推导出参考标准骨密度。方法以医院为基础的横断面研究对20岁接受CT检查的患者进行了研究，包括T12， L1和amp；L2椎体无明显骨病理。轴向CT系列用于计算骨密度。我们从20-39岁年龄组的患者中获得平均骨密度，计算平均值和标准差。后来，我们使用交叉表重新计算了所有年龄组患者的T评分，以确定在每个标准中有多少人属于骨质疏松症组[美国标准；加州大学旧金山分校（UCSF）标准、世界卫生组织（世卫组织）标准和当地衍生标准)。结果20 ~ 39岁男性和女性的平均骨密度分别为149.4 mg/cc2和152.5 mg/cc2。根据CT骨衰减，我们发现衰减>；120 Hounsfield unit （HU）没有骨质疏松，衰减>；200 HU按照我们的参考标准没有骨质减少。同样，当我们考虑UCSF标准值时，我们发现衰减>；180 HU没有任何骨质疏松，衰减>；240 HU没有任何骨质减少，而按照WHO标准衰减>；130 HU没有任何骨质疏松，衰减>；210 HU没有任何骨质减少。鉴于目前在老年人中进行的大量身体CT扫描用于各种临床适应症，这为扩大骨质疏松症筛查提供了独特的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.