Recent advancements of Raman spectroscopy application in topical products

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2025-05-08 DOI:10.1016/j.ejpb.2025.114738

Jing Pan , Xiaowei Liu , Haiwu Yang , Xiufeng Xu , Fang Tian , Keith C. Gordon , Cushla M. McGoverin , Xiaolong Huang

{"title":"Recent advancements of Raman spectroscopy application in topical products","authors":"Jing Pan , Xiaowei Liu , Haiwu Yang , Xiufeng Xu , Fang Tian , Keith C. Gordon , Cushla M. McGoverin , Xiaolong Huang","doi":"10.1016/j.ejpb.2025.114738","DOIUrl":null,"url":null,"abstract":"<div><div>Topical products have gained popularity in the recent years. Diverse formulation types, complex composition, and thermodynamically instable nature present great challenges in the formulation development of topical products. The analytical methods available for topical formulation analysis and quality control are limited. To improve formulation development of various topical products, especially when API is suspended as a crystalline form in the formulation or recrystallizes during application, methods for topical formulation performance analysis and evaluation are of vital importance. In this article, we review advancements in applying Raman spectroscopy to the characterization and evaluation of topical product performance. Furthermore, the potential application of artificial intelligence combined with Raman spectroscopy in enhancing topical formulation development in the future will be presented.</div></div>","PeriodicalId":12024,"journal":{"name":"European Journal of Pharmaceutics and Biopharmaceutics","volume":"212 ","pages":"Article 114738"},"PeriodicalIF":4.4000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmaceutics and Biopharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0939641125001158","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Topical products have gained popularity in the recent years. Diverse formulation types, complex composition, and thermodynamically instable nature present great challenges in the formulation development of topical products. The analytical methods available for topical formulation analysis and quality control are limited. To improve formulation development of various topical products, especially when API is suspended as a crystalline form in the formulation or recrystallizes during application, methods for topical formulation performance analysis and evaluation are of vital importance. In this article, we review advancements in applying Raman spectroscopy to the characterization and evaluation of topical product performance. Furthermore, the potential application of artificial intelligence combined with Raman spectroscopy in enhancing topical formulation development in the future will be presented.

查看原文本刊更多论文

拉曼光谱在外用产品中的应用进展

近年来，外用产品越来越受欢迎。剂型多样、成分复杂、热力学不稳定等特点给外用制剂的开发带来了很大的挑战。可用于外用制剂分析和质量控制的分析方法有限。为了改善各种外用产品的配方开发，特别是当原料药以结晶形式悬浮在配方中或在使用过程中再结晶时，外用配方性能分析和评价方法至关重要。在本文中，我们综述了应用拉曼光谱表征和评价外用产品性能的进展。展望了人工智能与拉曼光谱技术在促进外用制剂开发方面的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.