Optimizing near-infrared-activated gold nanostructures for targeted combination cancer therapy

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-07 DOI:10.1016/j.colsurfb.2025.114687

Nutan Shukla , Ratnesh Das , Carol Yazbleydy Cárdenas Rodriguez , Elizaveta Mukhanova , Alexander Soldatov , Aadil Bathla , Indu kumari , Nitin Hauserao , Sabrina Belbekhouche

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引用次数: 0

Abstract

The application of near-infrared (NIR)-activated gold nanostructures, particularly gold nanostars (AuNSs) and gold nanorods (AuNRs), has emerged as a promising strategy in targeted combination cancer therapy (Figure 1). These nanostructures leverage their unique localized surface plasmon resonance (LSPR) properties, which enable effective absorption and conversion of NIR light into heat, facilitating photothermal therapy (PTT) to selectively destroy cancer cells. Recent advancements in the synthesis and functionalization of AuNSs and AuNRs have enhanced their biocompatibility, stability, and therapeutic efficacy. This review highlights the mechanisms by which these gold nanostructures can be optimized for synergistic effects when combined with other therapeutic modalities such as chemotherapy and photodynamic therapy (PDT). We discuss the importance of surface modifications that improve tumor targeting and retention, as well as the potential to overcome limitations associated with conventional therapies. The integration of AuNSs and AuNRs into multi-faceted treatment regimens represents a significant step forward in the development of effective cancer therapies, aiming to maximize therapeutic outcomes while minimizing side effects.

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优化近红外活化金纳米结构用于靶向联合癌症治疗

近红外（NIR）活化的金纳米结构，特别是金纳米星（AuNSs）和金纳米棒（aunr）的应用，已经成为靶向联合癌症治疗的一种有前途的策略（图1）。这些纳米结构利用其独特的局部表面等离子体共振（LSPR）特性，能够有效地吸收近红外光并将其转化为热量，从而促进光热治疗（PTT）选择性地破坏癌细胞。近年来在AuNSs和aunr的合成和功能化方面取得的进展提高了它们的生物相容性、稳定性和治疗效果。这篇综述强调了这些金纳米结构在与化疗和光动力疗法（PDT）等其他治疗方式联合时可以优化协同效应的机制。我们讨论了表面修饰提高肿瘤靶向和保留的重要性，以及克服与传统疗法相关的局限性的潜力。将AuNSs和aunr整合到多方面的治疗方案中，是开发有效癌症治疗方法的重要一步，旨在最大化治疗效果，同时最小化副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.