Advanced multifunctional coatings in ureteral stents: Interfacial design, properties, and applications

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2025-05-08 DOI:10.1016/j.cis.2025.103542

Yucong Wu , Senwei Liu , Youzhun Fan , Jiawei Li , Yingshan Deng , Peng Yu , Chengyun Ning , Jinxia Zhai

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引用次数: 0

Abstract

Ureteral stents play an essential role in the clinical practice of managing both benign and malignant urinary tract disorders. However, their use is accompanied by various complications, including tissue damage, urinary tract infection, biofilm formation, and encrustation. Although ureteral stents demonstrate remarkable efficacy in alleviating urinary tract obstruction, the multifaceted complications stemming from the demanding physiological environment of the urinary system continue to present a formidable challenge to clinical management. Therefore, the strategies to develop multifunctional stents are critical to address the complex microenvironment of long-term indwelling urinary tract. This review initially examines the challenges associated with the urinary tract interface environment and outlines strategies to overcome them. It then highlights the state-of-the-art advances in multifunctional urinary stents and discusses customized solutions that meet clinical practice depending on the duration of stent indwelling. Finally, we discuss the potential for designing smart-responsive multifunctional coating technologies, designed for precision therapy. This review provides insight into the development of advanced ureteral stents

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输尿管支架中的先进多功能涂层：界面设计、性能和应用

输尿管支架在治疗良性和恶性尿路疾病的临床实践中发挥着重要作用。然而，它们的使用伴随着各种并发症，包括组织损伤、尿路感染、生物膜形成和结痂。尽管输尿管支架在缓解尿路梗阻方面表现出显著的疗效，但泌尿系统苛刻的生理环境导致的多方面并发症仍然是临床管理的巨大挑战。因此，开发多功能支架是解决长期留置尿路复杂微环境的关键。这篇综述初步探讨了与泌尿道界面环境相关的挑战，并概述了克服这些挑战的策略。然后重点介绍了多功能尿路支架的最新进展，并讨论了根据支架留置时间满足临床实践的定制解决方案。最后，我们讨论了设计用于精确治疗的智能响应多功能涂层技术的潜力。本文综述了晚期输尿管支架的发展

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.