Effect of nonsurgical periodontal therapy on coronary artery disease or metabolic syndrome: a systematic review and meta-analysis

IF 4.1 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-03-11 DOI:10.1016/j.jebdp.2025.102136

Yule Su , Yuhang Cao , Xingtao Bing , Chen Chen , Hongli Yan , Hongjiao Zhao , Yilin Wang , Shixin Liu , Yuchen Xie , Chanjuan Li , Yaqin Wang , Junhua Yuan

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引用次数: 0

Abstract

Background

Periodontitis is closely related to the occurrence and development of coronary artery disease (CAD) and metabolic syndrome (MetS). However, the role of nonsurgical periodontal therapy (NSPT) in these 2 diseases is still controversial. To investigate the efficacy of NSPT in managing individuals with CAD or MetS and the differences in effects and benefits of NSPT between the 2 patient populations.

Methods

Literature was searched in PubMed, Embase, Cochrane, CNKI, VIP, and Wanfang databases from their inception to August 2024. The effect measures were mean differences (MD) and 95% confidence interval (95% CI). Meta-analyses were performed using random-effects models. Subgroup analysis of health status, follow-up time, antibiotic use and periodontitis severity were performed.

Results

Twenty-one publications involving 1619 subjects were included. Comparing to the control, NSPT significantly reduced the levels of CRP ([MD] -0.61 mg/L; 95% CI -1.11 to -0.12), TNF-α ([MD] -3.48 pg/mL; 95% CI -4.49 to -2.48), IL-6 ([MD] -1.56 pg/mL; 95% CI -2.30 to -0.83), IL-8 ([MD] -1.56 pg/mL; 95% CI -3.95 to -1.59; I² = 56%) and fasting blood glucose ([MD] -5.81 mg/dL; 95% CI -9.96 to -1.67).

Conclusions

Meta-analysis showed that NSPT exerted beneficial effects on CAD by controlling systemic inflammation levels, which was not observed in patients with MetS.

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非手术牙周治疗对冠状动脉疾病或代谢综合征的影响：系统回顾和荟萃分析

背景牙周炎与冠状动脉疾病（CAD）和代谢综合征（MetS）的发生发展密切相关。然而，非手术牙周治疗（NSPT）在这两种疾病中的作用仍存在争议。目的：探讨NSPT治疗CAD或MetS患者的疗效，以及NSPT在两种患者群体中的效果和益处的差异。方法检索PubMed、Embase、Cochrane、CNKI、VIP、万方等数据库自建站至2024年8月的文献。效果测量为平均差异（MD）和95%置信区间（95% CI）。采用随机效应模型进行meta分析。对健康状况、随访时间、抗生素使用情况和牙周炎严重程度进行亚组分析。结果共纳入文献21篇，涉及受试者1619名。与对照组相比，NSPT显著降低CRP水平([MD] -0.61 mg/L；95% CI为-1.11 ~ -0.12),TNF-α ([MD] -3.48 pg/mL；95% CI -4.49 ~ -2.48), IL-6 ([MD] -1.56 pg/mL；95% CI -2.30 ~ -0.83), IL-8 ([MD] -1.56 pg/mL；95% CI -3.95 ~ -1.59；I2 = 56%)和空腹血糖([MD] -5.81 mg/dL；95% CI -9.96 ~ -1.67)。结论meta分析显示，NSPT通过控制全身炎症水平对CAD有有益作用，而在MetS患者中未观察到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.